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An alumina toughened zirconia composite for dental implant application: in vivo animal results.

Schierano G, Mussano F, Faga MG, Menicucci G, Manzella C, Sabione C, Genova T, von Degerfeld MM, Peirone B, Cassenti A, Cassoni P, Carossa S - Biomed Res Int (2015)

Bottom Line: The novel ATZ implant was compared to a titanium clinical standard.The implants were analyzed in terms of microstructure and surface roughness before in vivo tests.Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.

ABSTRACT
Ceramic materials are widely used for biomedical applications because of their remarkable biological and mechanical properties. Composites made of alumina and zirconia are particularly interesting owing to their higher toughness with respect to the monolithic materials. On this basis, the present study is focused on the in vivo behavior of alumina toughened zirconia (ATZ) dental implants treated with a hydrothermal process. A minipig model was implemented to assess the bone healing through histology and mRNA expression at different time points (8, 14, 28, and 56 days). The novel ATZ implant was compared to a titanium clinical standard. The implants were analyzed in terms of microstructure and surface roughness before in vivo tests. The most interesting result deals with a statistically significant higher digital histology index for ATZ implants with respect to titanium standard at 56 days, which is an unprecedented finding, to the authors' knowledge. Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.

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Related in: MedlinePlus

Digital Histology Index (DHI). Note: The DHI values differed in a statistically significant way (Student's t-test P < 0.001) between the alumina toughened zirconia (ATZ) and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At 28 days no significant difference could be found (ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4).
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fig7: Digital Histology Index (DHI). Note: The DHI values differed in a statistically significant way (Student's t-test P < 0.001) between the alumina toughened zirconia (ATZ) and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At 28 days no significant difference could be found (ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4).

Mentions: Both treatment and control groups showed a steady increase in the overall digital histology index up to 56 days (Figure 6). The DHI values differed in a statistically significant way between the ATZ and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At the earlier time points, no significant difference could be found (at 28 days: ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4) (Figure 7).


An alumina toughened zirconia composite for dental implant application: in vivo animal results.

Schierano G, Mussano F, Faga MG, Menicucci G, Manzella C, Sabione C, Genova T, von Degerfeld MM, Peirone B, Cassenti A, Cassoni P, Carossa S - Biomed Res Int (2015)

Digital Histology Index (DHI). Note: The DHI values differed in a statistically significant way (Student's t-test P < 0.001) between the alumina toughened zirconia (ATZ) and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At 28 days no significant difference could be found (ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4).
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4402487&req=5

fig7: Digital Histology Index (DHI). Note: The DHI values differed in a statistically significant way (Student's t-test P < 0.001) between the alumina toughened zirconia (ATZ) and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At 28 days no significant difference could be found (ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4).
Mentions: Both treatment and control groups showed a steady increase in the overall digital histology index up to 56 days (Figure 6). The DHI values differed in a statistically significant way between the ATZ and the titanium samples at day 56 (ATZ = 53.3% ± 6.5, Ti = 35.3% ± 1.9). At the earlier time points, no significant difference could be found (at 28 days: ATZ = 45.4% ± 4.5, Ti = 32.1% ± 6.4) (Figure 7).

Bottom Line: The novel ATZ implant was compared to a titanium clinical standard.The implants were analyzed in terms of microstructure and surface roughness before in vivo tests.Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgical Sciences, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.

ABSTRACT
Ceramic materials are widely used for biomedical applications because of their remarkable biological and mechanical properties. Composites made of alumina and zirconia are particularly interesting owing to their higher toughness with respect to the monolithic materials. On this basis, the present study is focused on the in vivo behavior of alumina toughened zirconia (ATZ) dental implants treated with a hydrothermal process. A minipig model was implemented to assess the bone healing through histology and mRNA expression at different time points (8, 14, 28, and 56 days). The novel ATZ implant was compared to a titanium clinical standard. The implants were analyzed in terms of microstructure and surface roughness before in vivo tests. The most interesting result deals with a statistically significant higher digital histology index for ATZ implants with respect to titanium standard at 56 days, which is an unprecedented finding, to the authors' knowledge. Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.

No MeSH data available.


Related in: MedlinePlus