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Role of gut barrier function in the pathogenesis of nonalcoholic Fatty liver disease.

Dai X, Wang B - Gastroenterol Res Pract (2015)

Bottom Line: Many efforts have been made to investigate the pathogenesis of this disease.Since 1998 when Marshall proposed the conception of "gut-liver axis," more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD.In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical University General Hospital, Tianjin 300052, China.

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, and its incidence is increasing year by year. Many efforts have been made to investigate the pathogenesis of this disease. Since 1998 when Marshall proposed the conception of "gut-liver axis," more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD. The four aspects of gut barrier function, including physical, chemical, biological, and immunological barriers, are interrelated closely and related to NAFLD. In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.

No MeSH data available.


Related in: MedlinePlus

Gut-liver axis in NAFLD.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Gut-liver axis in NAFLD.

Mentions: The four aspects of gut barrier function including physical, chemical, biological, and immunological barriers are closely related to each other and inseparable from NAFLD (Figure 1). For instance, intestinal epithelial cells are important part of physical barrier. When the permeability of physical barrier is increased, LPS will rush into portal system and induce the progress of NAFLD. At the same time, TLRs, the important member of innate immunity, are also expressed in the epithelium and their signal transduction is relevant with NAFLD. The ligand of TLRs is PAMPs from microbiome. The intestinal microbiota has a major role in shaping the host immune response and commensal bacteria shape the integrity of the gut mucosa [46]. The exchange of gut flora can lead to the abnormal accumulation of triglyceride in liver through inhibiting the synthesis and secretion of VLDL and LDL and finally cause NAFLD. IgA, a critical part of immunological barrier, works as the protector of gut mucosa through coating the Gram-negative bacilli and takes effect. The alteration of gut flora leads to the increasing of alcohol in lumen and destroys the intact of gut mucosa and physical barrier. No matter which aspect of gut barrier is destroyed, the other aspects will also be impaired and all of them combine together to cause the occurrence and development of NAFLD.


Role of gut barrier function in the pathogenesis of nonalcoholic Fatty liver disease.

Dai X, Wang B - Gastroenterol Res Pract (2015)

Gut-liver axis in NAFLD.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402198&req=5

fig1: Gut-liver axis in NAFLD.
Mentions: The four aspects of gut barrier function including physical, chemical, biological, and immunological barriers are closely related to each other and inseparable from NAFLD (Figure 1). For instance, intestinal epithelial cells are important part of physical barrier. When the permeability of physical barrier is increased, LPS will rush into portal system and induce the progress of NAFLD. At the same time, TLRs, the important member of innate immunity, are also expressed in the epithelium and their signal transduction is relevant with NAFLD. The ligand of TLRs is PAMPs from microbiome. The intestinal microbiota has a major role in shaping the host immune response and commensal bacteria shape the integrity of the gut mucosa [46]. The exchange of gut flora can lead to the abnormal accumulation of triglyceride in liver through inhibiting the synthesis and secretion of VLDL and LDL and finally cause NAFLD. IgA, a critical part of immunological barrier, works as the protector of gut mucosa through coating the Gram-negative bacilli and takes effect. The alteration of gut flora leads to the increasing of alcohol in lumen and destroys the intact of gut mucosa and physical barrier. No matter which aspect of gut barrier is destroyed, the other aspects will also be impaired and all of them combine together to cause the occurrence and development of NAFLD.

Bottom Line: Many efforts have been made to investigate the pathogenesis of this disease.Since 1998 when Marshall proposed the conception of "gut-liver axis," more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD.In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.

View Article: PubMed Central - PubMed

Affiliation: Tianjin Medical University General Hospital, Tianjin 300052, China.

ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease, and its incidence is increasing year by year. Many efforts have been made to investigate the pathogenesis of this disease. Since 1998 when Marshall proposed the conception of "gut-liver axis," more and more researchers have paid close attention to the role of gut barrier function in the pathogenesis of NAFLD. The four aspects of gut barrier function, including physical, chemical, biological, and immunological barriers, are interrelated closely and related to NAFLD. In this paper, we present a summary of research findings on the relationship between gut barrier dysfunction and the development of NAFLD, aiming at illustrating the role of gut barrier function in the pathogenesis of this disease.

No MeSH data available.


Related in: MedlinePlus