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Leiomyoma of the renal vein: a rare tumor presenting as a renal mass.

Kocak C, Kabay S, Isler B - Case Rep Urol (2015)

Bottom Line: Renal leiomyomas usually occur in the renal cortex or capsule.They are less commonly found in the muscularis propria of the renal pelvis and cortical vascular smooth muscle.In this case report, we present a 41-year-old woman who had right flank pain and detected a mass in the right kidney hilum.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine, Dumlupinar University, Evliya Celebi Campus, 43000 Kutahya, Turkey.

ABSTRACT
Leiomyomas are benign mesenchymal tumors that rarely occur in the kidney. Renal leiomyomas usually occur in the renal cortex or capsule. They are less commonly found in the muscularis propria of the renal pelvis and cortical vascular smooth muscle. In this case report, we present a 41-year-old woman who had right flank pain and detected a mass in the right kidney hilum.

No MeSH data available.


Related in: MedlinePlus

The relationship between tumoural tissue and renal vein (T: tumor, RV: renal vein, L: lumen, and W: wall; H&E ×40).
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fig4: The relationship between tumoural tissue and renal vein (T: tumor, RV: renal vein, L: lumen, and W: wall; H&E ×40).

Mentions: A 41-year-old woman was admitted to the department of urology with a complaint of right side pain; the history of the patient was unremarkable. Contrast-enhanced computed tomography (CECT) scan demonstrated a well-defined, lobulated mass lesion in the right kidney hilum, measuring 3.5 × 4.0 cm. Routine laboratory findings were within normal ranges. In view of the clinical and radiological features, prediagnosis of patient was considered as renal malign neoplasm. Laparotomy and right radical nephrectomy through left subcostal incision were made under general anesthesia. Macroscopic examination of the nephrectomy specimen revealed a tumour mass 4.0 × 3.5 × 3.0 cm in size attached to the right kidney at the hilum by a narrow isthmus of tumour (Figure 1). The tumour mass was well-defined, thinly encapsulated, and gray-white colored and demonstrated whorled pattern of smooth muscle bundles separated by connective tissue. Hemorrhage and necrotic foci and pericapsular or parenchymal spread were not seen. Biopsy samples were subjected to both pathology and immunohistochemical evaluation. Hematoxylin and eosin (H&E) staining revealed that the cellular, nodular neoplasm consisted of mesenchymal cells with spindle shaped nuclei, eosinophilic cytoplasm (Figure 2). Malignancy findings like cellular atypia, necrosis, and mitotic activity were not seen. The relationship between tumoural tissue and renal vein was observed in microscopic examination (Figures 3 and 4). Upon immunohistochemical examinations (Roche Ventana Benchmark-Bios, Arizona, USA, and Thermo Fisher Scientific Inc. MI, USA), while the neoplastic cells showed positive immunoreactivity for smooth muscle actin (SMA) (Figure 5), negative immunoreactivity was seen for S100, CD34, and human melanoma black 45 (HBM45). Considering all these features, the pathological diagnosis was leiomyoma originating from renal vein wall.


Leiomyoma of the renal vein: a rare tumor presenting as a renal mass.

Kocak C, Kabay S, Isler B - Case Rep Urol (2015)

The relationship between tumoural tissue and renal vein (T: tumor, RV: renal vein, L: lumen, and W: wall; H&E ×40).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402193&req=5

fig4: The relationship between tumoural tissue and renal vein (T: tumor, RV: renal vein, L: lumen, and W: wall; H&E ×40).
Mentions: A 41-year-old woman was admitted to the department of urology with a complaint of right side pain; the history of the patient was unremarkable. Contrast-enhanced computed tomography (CECT) scan demonstrated a well-defined, lobulated mass lesion in the right kidney hilum, measuring 3.5 × 4.0 cm. Routine laboratory findings were within normal ranges. In view of the clinical and radiological features, prediagnosis of patient was considered as renal malign neoplasm. Laparotomy and right radical nephrectomy through left subcostal incision were made under general anesthesia. Macroscopic examination of the nephrectomy specimen revealed a tumour mass 4.0 × 3.5 × 3.0 cm in size attached to the right kidney at the hilum by a narrow isthmus of tumour (Figure 1). The tumour mass was well-defined, thinly encapsulated, and gray-white colored and demonstrated whorled pattern of smooth muscle bundles separated by connective tissue. Hemorrhage and necrotic foci and pericapsular or parenchymal spread were not seen. Biopsy samples were subjected to both pathology and immunohistochemical evaluation. Hematoxylin and eosin (H&E) staining revealed that the cellular, nodular neoplasm consisted of mesenchymal cells with spindle shaped nuclei, eosinophilic cytoplasm (Figure 2). Malignancy findings like cellular atypia, necrosis, and mitotic activity were not seen. The relationship between tumoural tissue and renal vein was observed in microscopic examination (Figures 3 and 4). Upon immunohistochemical examinations (Roche Ventana Benchmark-Bios, Arizona, USA, and Thermo Fisher Scientific Inc. MI, USA), while the neoplastic cells showed positive immunoreactivity for smooth muscle actin (SMA) (Figure 5), negative immunoreactivity was seen for S100, CD34, and human melanoma black 45 (HBM45). Considering all these features, the pathological diagnosis was leiomyoma originating from renal vein wall.

Bottom Line: Renal leiomyomas usually occur in the renal cortex or capsule.They are less commonly found in the muscularis propria of the renal pelvis and cortical vascular smooth muscle.In this case report, we present a 41-year-old woman who had right flank pain and detected a mass in the right kidney hilum.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, Faculty of Medicine, Dumlupinar University, Evliya Celebi Campus, 43000 Kutahya, Turkey.

ABSTRACT
Leiomyomas are benign mesenchymal tumors that rarely occur in the kidney. Renal leiomyomas usually occur in the renal cortex or capsule. They are less commonly found in the muscularis propria of the renal pelvis and cortical vascular smooth muscle. In this case report, we present a 41-year-old woman who had right flank pain and detected a mass in the right kidney hilum.

No MeSH data available.


Related in: MedlinePlus