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Mast cell and autoimmune diseases.

Xu Y, Chen G - Mediators Inflamm. (2015)

Bottom Line: Mast cells are important in innate immune system.They have been appreciated as potent contributors to allergic reaction.However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.

ABSTRACT
Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases.

No MeSH data available.


Related in: MedlinePlus

Direct cell interaction between mast cells and B cells.
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Related In: Results  -  Collection


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fig2: Direct cell interaction between mast cells and B cells.

Mentions: MCs express a variety of B cell-modulating molecules and immunoglobulin (Ig) receptors [30]. MC FcRs include IgE and IgG receptors [34]. Depending upon the type of MCs, IgG-antigen complexes may activate MCs [34]. Conversely, the coengagement of IgG and IgE receptors inhibits cells activation [34]. Increasing data has been established indicating that MCs play critical roles in IgG-dependent tissue-specific autoimmune diseases [34]. Low amounts of MCs are effective in influencing B cell survival and proliferation in vitro through cell-cell contact and MC-derived IL-6 expression whatever state the MC activation is in [35]. Furthermore, MCs can promote B cells to differentiate into CD138+ plasma cells secreting IgA and it is dependent on CD40-CD40L expressed on B cells and MCs, respectively [35] (Figure 2).


Mast cell and autoimmune diseases.

Xu Y, Chen G - Mediators Inflamm. (2015)

Direct cell interaction between mast cells and B cells.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4402170&req=5

fig2: Direct cell interaction between mast cells and B cells.
Mentions: MCs express a variety of B cell-modulating molecules and immunoglobulin (Ig) receptors [30]. MC FcRs include IgE and IgG receptors [34]. Depending upon the type of MCs, IgG-antigen complexes may activate MCs [34]. Conversely, the coengagement of IgG and IgE receptors inhibits cells activation [34]. Increasing data has been established indicating that MCs play critical roles in IgG-dependent tissue-specific autoimmune diseases [34]. Low amounts of MCs are effective in influencing B cell survival and proliferation in vitro through cell-cell contact and MC-derived IL-6 expression whatever state the MC activation is in [35]. Furthermore, MCs can promote B cells to differentiate into CD138+ plasma cells secreting IgA and it is dependent on CD40-CD40L expressed on B cells and MCs, respectively [35] (Figure 2).

Bottom Line: Mast cells are important in innate immune system.They have been appreciated as potent contributors to allergic reaction.However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology, Shanghai 200025, China.

ABSTRACT
Mast cells are important in innate immune system. They have been appreciated as potent contributors to allergic reaction. However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. Here we review the current stage of knowledge about mast cells in autoimmune diseases.

No MeSH data available.


Related in: MedlinePlus