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Years of life lived with disease and years of potential life lost in children who die of cancer in the United States, 2009.

de Blank PM, Ostrom QT, Rouse C, Wolinsky Y, Kruchko C, Salcido J, Barnholtz-Sloan JS - Cancer Med (2015)

Bottom Line: For specific histologies, the greatest mean YPLL per death was due to atypical teratoid/rhabdoid tumor (78.0 years lost).The histology with the highest mean YLLD per death in children and adolescents who died of cancer was primitive neuroectodermal tumor (4.6 years lived).This offers the first histology-specific description of YPLL in children and adolescents and proposes a new measure of cancer impact, YLLD, in individuals who die of their disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Hematology-Oncology, Rainbow Babies and Children's Hospital, 11100 Euclid Ave, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Cleveland, Ohio.

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(A) Mean years of potential life lost (YPLL) due to selected tumor categories for persons 0–19 years old, (B) mean YPLL for selected central nervous system (CNS) tumor and leukemia histologies, (C) mean years of life lived with disease (YLLD) prior to death for persons 0–19 years old by selected tumor categories, (D) mean YLLD for selected CNS and leukemia histologies, (E) median age at diagnosis death by selected histologies, and (F) median age at diagnosis and death by selected CNS and leukemia histologies (SEER).
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fig03: (A) Mean years of potential life lost (YPLL) due to selected tumor categories for persons 0–19 years old, (B) mean YPLL for selected central nervous system (CNS) tumor and leukemia histologies, (C) mean years of life lived with disease (YLLD) prior to death for persons 0–19 years old by selected tumor categories, (D) mean YLLD for selected CNS and leukemia histologies, (E) median age at diagnosis death by selected histologies, and (F) median age at diagnosis and death by selected CNS and leukemia histologies (SEER).

Mentions: CNS tumors caused the highest loss of potential life years, followed by leukemia, non-Hodgkin lymphoma, and Hodgkin lymphoma (Fig.3A). Among all specific histologies examined, the histologic types with the highest mean YPLL were atypical teratoid/rhabdoid tumors (ATRT, ICD-O-3 histology code: 9508) (mean YPLL = 78.04) and high-grade gliomas (ICD-O-3 histology codes: 9381, 9401, 9440-9442, 9451, 9460 for all sites, 9380 and 9400 only for site code C71.7) (mean YPLL = 70.67) (Fig.3B). Mean YLLD was not significantly different between CNS tumors and other common childhood cancers in children and adolescents who die of cancer before 20 years of age (leukemia P = 0.224, non-Hodgkin lymphoma P = 0.308, and Hodgkin lymphoma P = 0.623) (Table3). The histologies with the highest mean YLLD were primitive neuroectodermal tumor (PNET) (mean YLLD = 4.59), medulloblastoma (mean YLLD = 3.17), and acute lymphoblastic leukemia (mean YLLD = 3.09). The histology with the lowest mean YLLD was ATRT (mean YLLD = 0.63). Individuals who died of gliomas, non-Hodgkin lymphoma, Hodgkin lymphoma, and myeloid leukemia lived the shortest after diagnosis on average (Fig.3C). There was a significant difference between the different embryonal subtypes: PNET had the longest mean YLLD, while ATRT had the shortest followed by acute myeloid leukemia (Fig.3D). Those diagnosed with gliomas and embryonal tumors died at the youngest median ages, while those diagnosed with non-Hodgkin lymphoma or Hodgkin lymphoma died at the oldest median ages (Fig.3E). Of all embryonal tumors, ATRT had both the lowest median age of diagnosis and death (Fig.3F).


Years of life lived with disease and years of potential life lost in children who die of cancer in the United States, 2009.

de Blank PM, Ostrom QT, Rouse C, Wolinsky Y, Kruchko C, Salcido J, Barnholtz-Sloan JS - Cancer Med (2015)

(A) Mean years of potential life lost (YPLL) due to selected tumor categories for persons 0–19 years old, (B) mean YPLL for selected central nervous system (CNS) tumor and leukemia histologies, (C) mean years of life lived with disease (YLLD) prior to death for persons 0–19 years old by selected tumor categories, (D) mean YLLD for selected CNS and leukemia histologies, (E) median age at diagnosis death by selected histologies, and (F) median age at diagnosis and death by selected CNS and leukemia histologies (SEER).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402075&req=5

fig03: (A) Mean years of potential life lost (YPLL) due to selected tumor categories for persons 0–19 years old, (B) mean YPLL for selected central nervous system (CNS) tumor and leukemia histologies, (C) mean years of life lived with disease (YLLD) prior to death for persons 0–19 years old by selected tumor categories, (D) mean YLLD for selected CNS and leukemia histologies, (E) median age at diagnosis death by selected histologies, and (F) median age at diagnosis and death by selected CNS and leukemia histologies (SEER).
Mentions: CNS tumors caused the highest loss of potential life years, followed by leukemia, non-Hodgkin lymphoma, and Hodgkin lymphoma (Fig.3A). Among all specific histologies examined, the histologic types with the highest mean YPLL were atypical teratoid/rhabdoid tumors (ATRT, ICD-O-3 histology code: 9508) (mean YPLL = 78.04) and high-grade gliomas (ICD-O-3 histology codes: 9381, 9401, 9440-9442, 9451, 9460 for all sites, 9380 and 9400 only for site code C71.7) (mean YPLL = 70.67) (Fig.3B). Mean YLLD was not significantly different between CNS tumors and other common childhood cancers in children and adolescents who die of cancer before 20 years of age (leukemia P = 0.224, non-Hodgkin lymphoma P = 0.308, and Hodgkin lymphoma P = 0.623) (Table3). The histologies with the highest mean YLLD were primitive neuroectodermal tumor (PNET) (mean YLLD = 4.59), medulloblastoma (mean YLLD = 3.17), and acute lymphoblastic leukemia (mean YLLD = 3.09). The histology with the lowest mean YLLD was ATRT (mean YLLD = 0.63). Individuals who died of gliomas, non-Hodgkin lymphoma, Hodgkin lymphoma, and myeloid leukemia lived the shortest after diagnosis on average (Fig.3C). There was a significant difference between the different embryonal subtypes: PNET had the longest mean YLLD, while ATRT had the shortest followed by acute myeloid leukemia (Fig.3D). Those diagnosed with gliomas and embryonal tumors died at the youngest median ages, while those diagnosed with non-Hodgkin lymphoma or Hodgkin lymphoma died at the oldest median ages (Fig.3E). Of all embryonal tumors, ATRT had both the lowest median age of diagnosis and death (Fig.3F).

Bottom Line: For specific histologies, the greatest mean YPLL per death was due to atypical teratoid/rhabdoid tumor (78.0 years lost).The histology with the highest mean YLLD per death in children and adolescents who died of cancer was primitive neuroectodermal tumor (4.6 years lived).This offers the first histology-specific description of YPLL in children and adolescents and proposes a new measure of cancer impact, YLLD, in individuals who die of their disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatric Hematology-Oncology, Rainbow Babies and Children's Hospital, 11100 Euclid Ave, Cleveland, Ohio; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Cleveland, Ohio.

Show MeSH
Related in: MedlinePlus