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Variability in the reported management of pulmonary metastases in osteosarcoma.

Bhattasali O, Vo AT, Roth M, Geller D, Randall RL, Gorlick R, Gill J - Cancer Med (2015)

Bottom Line: Thoracotomy was the preferred technique for surgical resection.When only unilateral findings were present, the majority of physicians did not explore the contralateral lung.The majority of respondents did not recommend resection if the pulmonary nodule disappeared following chemotherapy.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

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Related in: MedlinePlus

Timing of initiation of management and resection for 2.0 cma, 0.5 cmb, and multiple bilateralc nodules. an = 183 survey responders. Significantly more 2.0 cm are managed at pretreatment than multiple bilateral (P = 0.0235). bn = 183 survey responders. Significantly less 0.5 cm are managed after neoadjuvant therapy than 2.0 cm (P = 0.03). cn = 183 survey responders. Significantly less multiple bilateral nodules are managed after neoadjuvant therapy than 2.0 cm (P = 0.002). Decreased not option for the respondents in the case of 0.5 cm nodule or multiple bilateral nodules.
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fig01: Timing of initiation of management and resection for 2.0 cma, 0.5 cmb, and multiple bilateralc nodules. an = 183 survey responders. Significantly more 2.0 cm are managed at pretreatment than multiple bilateral (P = 0.0235). bn = 183 survey responders. Significantly less 0.5 cm are managed after neoadjuvant therapy than 2.0 cm (P = 0.03). cn = 183 survey responders. Significantly less multiple bilateral nodules are managed after neoadjuvant therapy than 2.0 cm (P = 0.002). Decreased not option for the respondents in the case of 0.5 cm nodule or multiple bilateral nodules.

Mentions: The majority of physicians (63%) chose to manage a unilateral 2 cm nodule after neoadjuvant chemotherapy was completed, whereas 10% chose to manage the nodule prior to initiation of treatment and 27% deferred management until completion of all planned chemotherapy. The percentage of respondents addressing the nodule at the time of completion of neoadjuvant chemotherapy decreased significantly when presented with the scenarios of 0.5 cm nodule and multiple bilateral nodules (51%, P = 0.03, and 46%, P = 0.002, respectively) (Fig.1).


Variability in the reported management of pulmonary metastases in osteosarcoma.

Bhattasali O, Vo AT, Roth M, Geller D, Randall RL, Gorlick R, Gill J - Cancer Med (2015)

Timing of initiation of management and resection for 2.0 cma, 0.5 cmb, and multiple bilateralc nodules. an = 183 survey responders. Significantly more 2.0 cm are managed at pretreatment than multiple bilateral (P = 0.0235). bn = 183 survey responders. Significantly less 0.5 cm are managed after neoadjuvant therapy than 2.0 cm (P = 0.03). cn = 183 survey responders. Significantly less multiple bilateral nodules are managed after neoadjuvant therapy than 2.0 cm (P = 0.002). Decreased not option for the respondents in the case of 0.5 cm nodule or multiple bilateral nodules.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402067&req=5

fig01: Timing of initiation of management and resection for 2.0 cma, 0.5 cmb, and multiple bilateralc nodules. an = 183 survey responders. Significantly more 2.0 cm are managed at pretreatment than multiple bilateral (P = 0.0235). bn = 183 survey responders. Significantly less 0.5 cm are managed after neoadjuvant therapy than 2.0 cm (P = 0.03). cn = 183 survey responders. Significantly less multiple bilateral nodules are managed after neoadjuvant therapy than 2.0 cm (P = 0.002). Decreased not option for the respondents in the case of 0.5 cm nodule or multiple bilateral nodules.
Mentions: The majority of physicians (63%) chose to manage a unilateral 2 cm nodule after neoadjuvant chemotherapy was completed, whereas 10% chose to manage the nodule prior to initiation of treatment and 27% deferred management until completion of all planned chemotherapy. The percentage of respondents addressing the nodule at the time of completion of neoadjuvant chemotherapy decreased significantly when presented with the scenarios of 0.5 cm nodule and multiple bilateral nodules (51%, P = 0.03, and 46%, P = 0.002, respectively) (Fig.1).

Bottom Line: Thoracotomy was the preferred technique for surgical resection.When only unilateral findings were present, the majority of physicians did not explore the contralateral lung.The majority of respondents did not recommend resection if the pulmonary nodule disappeared following chemotherapy.

View Article: PubMed Central - PubMed

Affiliation: Division of Pediatric Hematology/Oncology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York.

Show MeSH
Related in: MedlinePlus