Functional MRI of music emotion processing in frontotemporal dementia.
Bottom Line: Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction.In a passive-listening paradigm, we manipulated levels of emotion processing in simple arpeggio chords (mode versus dissonance) and emotion modality (music versus human emotional vocalizations).A complex profile of disease-associated functional alterations was identified with separable signatures of musical mode, emotion level, and emotion modality within a common, distributed brain network, including posterior and anterior superior temporal and inferior frontal cortices and dorsal brainstem effector nuclei.
Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.Show MeSH
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Mentions: Significant activations for the experimental contrasts of interest are summarized in Table1, and statistical parametric maps and condition mean parameter estimates are displayed in Figure1. Auditory stimulation per se in both patients and healthy older individuals produced bilateral activation of auditory cortex including Heschl's gyrus, planum temporale, and superior temporal gyrus (P < 0.05, FWE whole brain), with no significant between-group differences.
Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.