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Functional MRI of music emotion processing in frontotemporal dementia.

Agustus JL, Mahoney CJ, Downey LE, Omar R, Cohen M, White MJ, Scott SK, Mancini L, Warren JD - Ann. N. Y. Acad. Sci. (2015)

Bottom Line: Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction.In a passive-listening paradigm, we manipulated levels of emotion processing in simple arpeggio chords (mode versus dissonance) and emotion modality (music versus human emotional vocalizations).A complex profile of disease-associated functional alterations was identified with separable signatures of musical mode, emotion level, and emotion modality within a common, distributed brain network, including posterior and anterior superior temporal and inferior frontal cortices and dorsal brainstem effector nuclei.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

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Statistical parametric maps (SPMs; left panels) of significant between-group contrasts and effect sizes (group mean ± SD peak voxel β parameter estimates; right panels) in key music emotion conditions for behavioral variant frontotemporal dementia (bvFTD) and healthy control groups. SPMs are rendered on a study-specific group anatomical image in MNI space (threshold P < 0.001 uncorrected over whole brain for display; see also Table1). Contrasts were based on interactions as follows: musical mode, ((MCM > MFC) × (controls > bvFTD)); music emotion level, ((MCD > MCM) × (control < bvFTD)); music-specific emotion, ((MCM > MFC) × (VC > VF) × (controls < bvFTD)). MFC, music fixed mode consonant; MCM, music changing mode; MCD, music changing dissonance; VC, vocal changing emotion; VF, vocal fixed emotion.
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fig01: Statistical parametric maps (SPMs; left panels) of significant between-group contrasts and effect sizes (group mean ± SD peak voxel β parameter estimates; right panels) in key music emotion conditions for behavioral variant frontotemporal dementia (bvFTD) and healthy control groups. SPMs are rendered on a study-specific group anatomical image in MNI space (threshold P < 0.001 uncorrected over whole brain for display; see also Table1). Contrasts were based on interactions as follows: musical mode, ((MCM > MFC) × (controls > bvFTD)); music emotion level, ((MCD > MCM) × (control < bvFTD)); music-specific emotion, ((MCM > MFC) × (VC > VF) × (controls < bvFTD)). MFC, music fixed mode consonant; MCM, music changing mode; MCD, music changing dissonance; VC, vocal changing emotion; VF, vocal fixed emotion.

Mentions: Significant activations for the experimental contrasts of interest are summarized in Table1, and statistical parametric maps and condition mean parameter estimates are displayed in Figure1. Auditory stimulation per se in both patients and healthy older individuals produced bilateral activation of auditory cortex including Heschl's gyrus, planum temporale, and superior temporal gyrus (P < 0.05, FWE whole brain), with no significant between-group differences.


Functional MRI of music emotion processing in frontotemporal dementia.

Agustus JL, Mahoney CJ, Downey LE, Omar R, Cohen M, White MJ, Scott SK, Mancini L, Warren JD - Ann. N. Y. Acad. Sci. (2015)

Statistical parametric maps (SPMs; left panels) of significant between-group contrasts and effect sizes (group mean ± SD peak voxel β parameter estimates; right panels) in key music emotion conditions for behavioral variant frontotemporal dementia (bvFTD) and healthy control groups. SPMs are rendered on a study-specific group anatomical image in MNI space (threshold P < 0.001 uncorrected over whole brain for display; see also Table1). Contrasts were based on interactions as follows: musical mode, ((MCM > MFC) × (controls > bvFTD)); music emotion level, ((MCD > MCM) × (control < bvFTD)); music-specific emotion, ((MCM > MFC) × (VC > VF) × (controls < bvFTD)). MFC, music fixed mode consonant; MCM, music changing mode; MCD, music changing dissonance; VC, vocal changing emotion; VF, vocal fixed emotion.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4402026&req=5

fig01: Statistical parametric maps (SPMs; left panels) of significant between-group contrasts and effect sizes (group mean ± SD peak voxel β parameter estimates; right panels) in key music emotion conditions for behavioral variant frontotemporal dementia (bvFTD) and healthy control groups. SPMs are rendered on a study-specific group anatomical image in MNI space (threshold P < 0.001 uncorrected over whole brain for display; see also Table1). Contrasts were based on interactions as follows: musical mode, ((MCM > MFC) × (controls > bvFTD)); music emotion level, ((MCD > MCM) × (control < bvFTD)); music-specific emotion, ((MCM > MFC) × (VC > VF) × (controls < bvFTD)). MFC, music fixed mode consonant; MCM, music changing mode; MCD, music changing dissonance; VC, vocal changing emotion; VF, vocal fixed emotion.
Mentions: Significant activations for the experimental contrasts of interest are summarized in Table1, and statistical parametric maps and condition mean parameter estimates are displayed in Figure1. Auditory stimulation per se in both patients and healthy older individuals produced bilateral activation of auditory cortex including Heschl's gyrus, planum temporale, and superior temporal gyrus (P < 0.05, FWE whole brain), with no significant between-group differences.

Bottom Line: Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction.In a passive-listening paradigm, we manipulated levels of emotion processing in simple arpeggio chords (mode versus dissonance) and emotion modality (music versus human emotional vocalizations).A complex profile of disease-associated functional alterations was identified with separable signatures of musical mode, emotion level, and emotion modality within a common, distributed brain network, including posterior and anterior superior temporal and inferior frontal cortices and dorsal brainstem effector nuclei.

View Article: PubMed Central - PubMed

Affiliation: Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

Show MeSH
Related in: MedlinePlus