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Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.

Roshanravan N, Alizadeh M, Hedayati M, Asghari-Jafarabadi M, Mesri Alamdari N, Anari F, Tarighat-Esfanjani A - Iran. J. Public Health (2015)

Bottom Line: Both mothers and newborns are typically at increased risk for complications.Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group.Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Biochemistry and Diet Therapy, Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Background: Hyperglycemia and gestational diabetes mellitus are complications of pregnancy. Both mothers and newborns are typically at increased risk for complications. This study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.

Methods: In this clinical trial 44 pregnant women with impaired glucose tolerance, from December 2012 -April 2013 were randomly divided into zinc (n=22) and placebo (n=22) groups and recived 30mg/day zinc gluconate and (n=22), and placebo for eight consecutive weeks respectively. Dietary food intake was estimated from 3-days diet records. Serum levels of zinc, fasting blood sugar, and insulin were measured by conventional methods. Also homeostatic model assessment of insulin resistance was calculated.

Results: Serumlevels of fasting blood sugar, insulin and homeostatic model assessment of insulin resistance slightly decreased in zinc group, but these changes were not statistically significant. Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group.

Conclusion: Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels.

No MeSH data available.


Related in: MedlinePlus

Flowchart of design and protocol of the study
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Figure 1: Flowchart of design and protocol of the study

Mentions: Daily total energy and macronutrients intakes are depicted in Table 3. Supplementation with 30mg of zinc significantly increased energy, protein, and fat and zinc intake in zinc group (P < 0.05). However, no change was observed in the placebo group (P >0.05). Flowchart of design and protocol of the study is shown (Fig. 1).


Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.

Roshanravan N, Alizadeh M, Hedayati M, Asghari-Jafarabadi M, Mesri Alamdari N, Anari F, Tarighat-Esfanjani A - Iran. J. Public Health (2015)

Flowchart of design and protocol of the study
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401879&req=5

Figure 1: Flowchart of design and protocol of the study
Mentions: Daily total energy and macronutrients intakes are depicted in Table 3. Supplementation with 30mg of zinc significantly increased energy, protein, and fat and zinc intake in zinc group (P < 0.05). However, no change was observed in the placebo group (P >0.05). Flowchart of design and protocol of the study is shown (Fig. 1).

Bottom Line: Both mothers and newborns are typically at increased risk for complications.Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group.Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels.

View Article: PubMed Central - PubMed

Affiliation: Dept. of Biochemistry and Diet Therapy, Student Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

ABSTRACT

Background: Hyperglycemia and gestational diabetes mellitus are complications of pregnancy. Both mothers and newborns are typically at increased risk for complications. This study sought to determine effect of zinc supplementation on serum glucose levels, insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance.

Methods: In this clinical trial 44 pregnant women with impaired glucose tolerance, from December 2012 -April 2013 were randomly divided into zinc (n=22) and placebo (n=22) groups and recived 30mg/day zinc gluconate and (n=22), and placebo for eight consecutive weeks respectively. Dietary food intake was estimated from 3-days diet records. Serum levels of zinc, fasting blood sugar, and insulin were measured by conventional methods. Also homeostatic model assessment of insulin resistance was calculated.

Results: Serumlevels of fasting blood sugar, insulin and homeostatic model assessment of insulin resistance slightly decreased in zinc group, but these changes were not statistically significant. Serum zinc levels (P =0.012), energy (P=0.037), protein (P=0.019) and fat (P=0.017) intakes increased statistically significant in the zinc group after intervention but not in the placebo group.

Conclusion: Oral supplementation with zinc could be effective in increasing serum zinc levels and energy intake with no effects on fasting blood sugar, homeostatic model assessment of insulin resistance and insulin levels.

No MeSH data available.


Related in: MedlinePlus