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Nationwide registry-based ecological analysis of Q fever incidence and pregnancy outcome during an outbreak in the Netherlands.

de Lange MM, Hukkelhoven CW, Munster JM, Schneeberger PM, van der Hoek W - BMJ Open (2015)

Bottom Line: In contrast, we found a weak significant association between residing in a Q fever-affected area in 2008-2010 and small for gestational age (adjusted OR 1.06 (95% CI 1.01 to 1.12)), with a population-attributable fraction of 0.70% (95% CI 0.07% to 1.34%).This study found a weak association between residing in a Q fever-affected area and the pregnancy outcome small for gestational age.Early detection of infection would require mass screening of pregnant women; this does not seem to be justified considering these results, and the uncertainties about its efficacy and the adverse effects of antibiotic treatment.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

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Postal-code areas affected by Q fever (2 or more notifications in 1 year during the years 2008, 2009 and 2010) and postal-code areas not affected by Q fever.
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BMJOPEN2014006821F1: Postal-code areas affected by Q fever (2 or more notifications in 1 year during the years 2008, 2009 and 2010) and postal-code areas not affected by Q fever.

Mentions: Areas not affected by Q fever were selected in two stages. First, four-digit postal-code areas with zero Q fever notifications in 2008 through 2010 were identified. Then, for each Q fever-affected area, we selected three postal-code areas not affected by Q fever (figure 1), which resembled the affected area in their proportion of adverse pregnancy outcomes in 2003 through 2004 (before the Q fever outbreak). With this method, we created two area types (areas affected and not affected by Q fever) which were comparable with respect to the risk of obstetric complications before the start of the Q fever outbreak.


Nationwide registry-based ecological analysis of Q fever incidence and pregnancy outcome during an outbreak in the Netherlands.

de Lange MM, Hukkelhoven CW, Munster JM, Schneeberger PM, van der Hoek W - BMJ Open (2015)

Postal-code areas affected by Q fever (2 or more notifications in 1 year during the years 2008, 2009 and 2010) and postal-code areas not affected by Q fever.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401861&req=5

BMJOPEN2014006821F1: Postal-code areas affected by Q fever (2 or more notifications in 1 year during the years 2008, 2009 and 2010) and postal-code areas not affected by Q fever.
Mentions: Areas not affected by Q fever were selected in two stages. First, four-digit postal-code areas with zero Q fever notifications in 2008 through 2010 were identified. Then, for each Q fever-affected area, we selected three postal-code areas not affected by Q fever (figure 1), which resembled the affected area in their proportion of adverse pregnancy outcomes in 2003 through 2004 (before the Q fever outbreak). With this method, we created two area types (areas affected and not affected by Q fever) which were comparable with respect to the risk of obstetric complications before the start of the Q fever outbreak.

Bottom Line: In contrast, we found a weak significant association between residing in a Q fever-affected area in 2008-2010 and small for gestational age (adjusted OR 1.06 (95% CI 1.01 to 1.12)), with a population-attributable fraction of 0.70% (95% CI 0.07% to 1.34%).This study found a weak association between residing in a Q fever-affected area and the pregnancy outcome small for gestational age.Early detection of infection would require mass screening of pregnant women; this does not seem to be justified considering these results, and the uncertainties about its efficacy and the adverse effects of antibiotic treatment.

View Article: PubMed Central - PubMed

Affiliation: Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Show MeSH
Related in: MedlinePlus