Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.
Bottom Line: We found six eligible studies including 279 cases of patients with KD and 203 febrile controls.A high degree of heterogeneity was found using the Cochran Q statistic.Prospective large cohort studies are needed to help determine best cut-off values and further clarify the role of NT-proBNP in the diagnosis process of KD.
Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.Show MeSH
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Mentions: We used the QUADAS tool for study quality assessment. Figure 2 provides an overall impression of the methodological quality of the studies. All blood drawn was taken in proximity to the confirmation diagnosis. All patients were verified by the same reference standards in all studies. None of the included studies explained the withdrawals or uninterested results. Only two of six studies reported the physicians were blinded to the index test while verifying outcomes by reference standards. We could not exclude the possibility of incorporation bias.
Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.