Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.
Bottom Line: We found six eligible studies including 279 cases of patients with KD and 203 febrile controls.A high degree of heterogeneity was found using the Cochran Q statistic.Prospective large cohort studies are needed to help determine best cut-off values and further clarify the role of NT-proBNP in the diagnosis process of KD.
Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.Show MeSH
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Mentions: We included studies comparing patients with KD and patients with febrile illness unrelated to KD. For inclusion, studies were required to have a study population of paediatric patients. Studies that compared healthy controls were not eligible for inclusion, because they tend to overestimate the sensitivity and specificity. BNP assays from any manufacturer were eligible. We excluded case reports, case series, review articles, editorials, congress abstracts and clinical guidelines. The study inclusion and exclusion process is summarised in figure 1.
Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.