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Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.

Lin KH, Chang SS, Yu CW, Lin SC, Liu SC, Chao HY, Lee MT, Wu JY, Lee CC - BMJ Open (2015)

Bottom Line: We found six eligible studies including 279 cases of patients with KD and 203 febrile controls.A high degree of heterogeneity was found using the Cochran Q statistic.Prospective large cohort studies are needed to help determine best cut-off values and further clarify the role of NT-proBNP in the diagnosis process of KD.

View Article: PubMed Central - PubMed

Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.

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Flow chart describing systematic literature search and study selection process.
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BMJOPEN2014006703F1: Flow chart describing systematic literature search and study selection process.

Mentions: We included studies comparing patients with KD and patients with febrile illness unrelated to KD. For inclusion, studies were required to have a study population of paediatric patients. Studies that compared healthy controls were not eligible for inclusion, because they tend to overestimate the sensitivity and specificity. BNP assays from any manufacturer were eligible. We excluded case reports, case series, review articles, editorials, congress abstracts and clinical guidelines. The study inclusion and exclusion process is summarised in figure 1.


Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis.

Lin KH, Chang SS, Yu CW, Lin SC, Liu SC, Chao HY, Lee MT, Wu JY, Lee CC - BMJ Open (2015)

Flow chart describing systematic literature search and study selection process.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401842&req=5

BMJOPEN2014006703F1: Flow chart describing systematic literature search and study selection process.
Mentions: We included studies comparing patients with KD and patients with febrile illness unrelated to KD. For inclusion, studies were required to have a study population of paediatric patients. Studies that compared healthy controls were not eligible for inclusion, because they tend to overestimate the sensitivity and specificity. BNP assays from any manufacturer were eligible. We excluded case reports, case series, review articles, editorials, congress abstracts and clinical guidelines. The study inclusion and exclusion process is summarised in figure 1.

Bottom Line: We found six eligible studies including 279 cases of patients with KD and 203 febrile controls.A high degree of heterogeneity was found using the Cochran Q statistic.Prospective large cohort studies are needed to help determine best cut-off values and further clarify the role of NT-proBNP in the diagnosis process of KD.

View Article: PubMed Central - PubMed

Affiliation: College of Medicine, China Medical University, Taichung, Taiwan Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan.

Show MeSH
Related in: MedlinePlus