Chronic kidney disease as a risk factor for incident gout among men and women: retrospective cohort study using data from the Framingham Heart Study.
Bottom Line: Excluding patients who had CKD in the first visit from this study, 2159 men and 2558 women were selected covering a 54-year period (1948-2002).Additional analyses using alternate definitions for CKD and cross-sectional study did not change the results.Sensitivity analysis suggested that the observed findings might be an underestimate of the true relative risk.
Affiliation: Stanford University School of Medicine, Palo Alto, California, USA.Show MeSH
Related in: MedlinePlus
Mentions: The incidence rate of gout was 6.82 (95% CI 5.10 to 9.10) per 1000 person-years among those with CKD and 2.43 (95% CI 2.18 to 2.71) among those without. Table 2 shows the incidence rates stratified by gender. The incidence rate in the CKD group for men was 10.24 (95% CI 7.02 to 14.93) and for women was 4.62 (95% CI 2.95 to 7.24). There were relatively few cases of gout in the first 20 years of follow-up. Figure 1 shows the Kaplan-Meier failure estimates for gout.
Affiliation: Stanford University School of Medicine, Palo Alto, California, USA.