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Leukocyte subtype counts and its association with vascular structure and function in adults with intermediate cardiovascular risk. MARK study.

Gomez-Sanchez L, García-Ortiz L, Recio-Rodríguez JI, Patino-Alonso MC, Agudo-Conde C, Rigo F, Ramos R, Martí R, Gomez-Marcos MA, MARK Gro - PLoS ONE (2015)

Bottom Line: The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender.In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients.These association were maintained after adjusting for age and other confounders.

View Article: PubMed Central - PubMed

Affiliation: Primary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain.

ABSTRACT

Objectives: We investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients.

Methods: This study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women.

Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx).

Results: Total leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (β = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (β = 2.445, p = 0.022) in women.

Conclusion: The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders.

Trial registration: ClinicalTrials.gov NCT01428934.

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Related in: MedlinePlus

Mean IMT values according to the neutrophil count tertiles in men; Neutrophil count tertiles: T1 < 3000/mm3; T2 3000 to 4000/mm3; T3 > 4000/mm3.CAIx in women values according to the monocyte count tertiles. Monocyte/count tertiles: 1° Tertile < 500 /mm3, 2° Tertile 500 to 600/mm3, 3° Tertile > 600 /mm3. ANOVA Test: Carotid intima media thickness by neutrophil count tertiles in men: p = 0.035; CAIx by monocyte count tertiles in women: p = 0.042.
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pone.0119963.g001: Mean IMT values according to the neutrophil count tertiles in men; Neutrophil count tertiles: T1 < 3000/mm3; T2 3000 to 4000/mm3; T3 > 4000/mm3.CAIx in women values according to the monocyte count tertiles. Monocyte/count tertiles: 1° Tertile < 500 /mm3, 2° Tertile 500 to 600/mm3, 3° Tertile > 600 /mm3. ANOVA Test: Carotid intima media thickness by neutrophil count tertiles in men: p = 0.035; CAIx by monocyte count tertiles in women: p = 0.042.

Mentions: Fig. 1 shows the values of the IMT by neutrophil count tertiles and the CAIx by monocyte count tertiles.


Leukocyte subtype counts and its association with vascular structure and function in adults with intermediate cardiovascular risk. MARK study.

Gomez-Sanchez L, García-Ortiz L, Recio-Rodríguez JI, Patino-Alonso MC, Agudo-Conde C, Rigo F, Ramos R, Martí R, Gomez-Marcos MA, MARK Gro - PLoS ONE (2015)

Mean IMT values according to the neutrophil count tertiles in men; Neutrophil count tertiles: T1 < 3000/mm3; T2 3000 to 4000/mm3; T3 > 4000/mm3.CAIx in women values according to the monocyte count tertiles. Monocyte/count tertiles: 1° Tertile < 500 /mm3, 2° Tertile 500 to 600/mm3, 3° Tertile > 600 /mm3. ANOVA Test: Carotid intima media thickness by neutrophil count tertiles in men: p = 0.035; CAIx by monocyte count tertiles in women: p = 0.042.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401724&req=5

pone.0119963.g001: Mean IMT values according to the neutrophil count tertiles in men; Neutrophil count tertiles: T1 < 3000/mm3; T2 3000 to 4000/mm3; T3 > 4000/mm3.CAIx in women values according to the monocyte count tertiles. Monocyte/count tertiles: 1° Tertile < 500 /mm3, 2° Tertile 500 to 600/mm3, 3° Tertile > 600 /mm3. ANOVA Test: Carotid intima media thickness by neutrophil count tertiles in men: p = 0.035; CAIx by monocyte count tertiles in women: p = 0.042.
Mentions: Fig. 1 shows the values of the IMT by neutrophil count tertiles and the CAIx by monocyte count tertiles.

Bottom Line: The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender.In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients.These association were maintained after adjusting for age and other confounders.

View Article: PubMed Central - PubMed

Affiliation: Primary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain.

ABSTRACT

Objectives: We investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients.

Methods: This study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3±8.4), 45.6% women.

Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx).

Results: Total leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (β = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (β = 2.445, p = 0.022) in women.

Conclusion: The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders.

Trial registration: ClinicalTrials.gov NCT01428934.

Show MeSH
Related in: MedlinePlus