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Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus

Analysis of the activity of left atrial inflammation (n = 6).Left atrial high sensitivity C-reactive protein (A) and interleukin-6 (B) levels in the three groups.
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pone.0124123.g009: Analysis of the activity of left atrial inflammation (n = 6).Left atrial high sensitivity C-reactive protein (A) and interleukin-6 (B) levels in the three groups.

Mentions: Left atrial tissue levels of hs-CRP and IL-6 were measured to represent the activity of inflammation (Fig 9A and 9B). Compared with the Sham group, levels of hs-CRP and IL-6 were increased by 61.4% and 73.8% respectively in the Model group (P < 0.05 for each). In the RDN group, levels of hs-CRP and IL-6 were reduced by 21.9% and 22.6% respectively, compared with the Model group (P < 0.05 for each).


Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Analysis of the activity of left atrial inflammation (n = 6).Left atrial high sensitivity C-reactive protein (A) and interleukin-6 (B) levels in the three groups.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401704&req=5

pone.0124123.g009: Analysis of the activity of left atrial inflammation (n = 6).Left atrial high sensitivity C-reactive protein (A) and interleukin-6 (B) levels in the three groups.
Mentions: Left atrial tissue levels of hs-CRP and IL-6 were measured to represent the activity of inflammation (Fig 9A and 9B). Compared with the Sham group, levels of hs-CRP and IL-6 were increased by 61.4% and 73.8% respectively in the Model group (P < 0.05 for each). In the RDN group, levels of hs-CRP and IL-6 were reduced by 21.9% and 22.6% respectively, compared with the Model group (P < 0.05 for each).

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus