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Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus

Analysis of the activity of SNS.Effects of RDN on the changes of plasma noradrenaline levels between values of 2 weeks and baseline (A) (n = 6). Left atrial noradrenaline levels in the three groups (B) (n = 6).
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pone.0124123.g007: Analysis of the activity of SNS.Effects of RDN on the changes of plasma noradrenaline levels between values of 2 weeks and baseline (A) (n = 6). Left atrial noradrenaline levels in the three groups (B) (n = 6).

Mentions: Plasma noradrenaline levels were measured to represent systematic activity of SNS. Sham operation did not change the plasma noradrenaline levels after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI induced a significant increase in plasma noradrenaline levels by 71.6%, compared with the baseline values in the Model group (P < 0.05). RDN reduced RI-induced increase in plasma noradrenaline levels by 42.5% (P < 0.05) (Fig 7A). Levels of noradrenaline in left atrial tissue were measured (Fig 7B). Compared with the Sham group, levels of noradrenaline were increased in the Model group by 42.3% (P < 0.05). In the RDN group, levels of noradrenaline were reduced by 12.6%, compared with the Model group P < 0.05).


Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Analysis of the activity of SNS.Effects of RDN on the changes of plasma noradrenaline levels between values of 2 weeks and baseline (A) (n = 6). Left atrial noradrenaline levels in the three groups (B) (n = 6).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401704&req=5

pone.0124123.g007: Analysis of the activity of SNS.Effects of RDN on the changes of plasma noradrenaline levels between values of 2 weeks and baseline (A) (n = 6). Left atrial noradrenaline levels in the three groups (B) (n = 6).
Mentions: Plasma noradrenaline levels were measured to represent systematic activity of SNS. Sham operation did not change the plasma noradrenaline levels after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI induced a significant increase in plasma noradrenaline levels by 71.6%, compared with the baseline values in the Model group (P < 0.05). RDN reduced RI-induced increase in plasma noradrenaline levels by 42.5% (P < 0.05) (Fig 7A). Levels of noradrenaline in left atrial tissue were measured (Fig 7B). Compared with the Sham group, levels of noradrenaline were increased in the Model group by 42.3% (P < 0.05). In the RDN group, levels of noradrenaline were reduced by 12.6%, compared with the Model group P < 0.05).

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus