Limits...
Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus

Atrial effective refractory period (AERP) analysis (n = 6).Effects of RDN on RI-induced AERP changes between values of 2 weeks and baseline at 300-ms basic cycle lengths (A) and at 240-ms basic cycle lengths (B).
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4401704&req=5

pone.0124123.g004: Atrial effective refractory period (AERP) analysis (n = 6).Effects of RDN on RI-induced AERP changes between values of 2 weeks and baseline at 300-ms basic cycle lengths (A) and at 240-ms basic cycle lengths (B).

Mentions: Sham operation did not change the AERP at 300-ms or at 240-ms basic cycle lengths after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI induced a pronounced AERP shortening at 300-ms basic cycle lengths and at 240-ms basic cycle lengths by 10.8% and 7.4% respectively, compared with the baseline values in the Model group (P < 0.05 for each). RDN completely prevented RI-induced AERP shortening at 300-ms basic cycle lengths and at 240-ms basic cycle lengths (P < 0.05 for each) (Fig 4A and 4B). Sham operation did not change the inducibility (Fig 5A) or duration of AF after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI resulted in a significant increase in AF inducibility by 1.5 fold (P < 0.05) (Fig 5B) and prolonged the duration of AF by 1.86 fold compared with the baseline values in the Model group (P < 0.05). The AF inducibility was unchanged after 2 weeks, compared with the baseline values in the RDN group (P > 0.05) (Fig 5C). RDN completely prevented RI-induced prolongation of AF duration (P < 0.05) (Fig 5D).


Renal denervation suppresses atrial fibrillation in a model of renal impairment.

Liang Z, Shi XM, Liu LF, Chen XP, Shan ZL, Lin K, Li J, Chen FK, Li YG, Guo HY, Wang YT - PLoS ONE (2015)

Atrial effective refractory period (AERP) analysis (n = 6).Effects of RDN on RI-induced AERP changes between values of 2 weeks and baseline at 300-ms basic cycle lengths (A) and at 240-ms basic cycle lengths (B).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401704&req=5

pone.0124123.g004: Atrial effective refractory period (AERP) analysis (n = 6).Effects of RDN on RI-induced AERP changes between values of 2 weeks and baseline at 300-ms basic cycle lengths (A) and at 240-ms basic cycle lengths (B).
Mentions: Sham operation did not change the AERP at 300-ms or at 240-ms basic cycle lengths after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI induced a pronounced AERP shortening at 300-ms basic cycle lengths and at 240-ms basic cycle lengths by 10.8% and 7.4% respectively, compared with the baseline values in the Model group (P < 0.05 for each). RDN completely prevented RI-induced AERP shortening at 300-ms basic cycle lengths and at 240-ms basic cycle lengths (P < 0.05 for each) (Fig 4A and 4B). Sham operation did not change the inducibility (Fig 5A) or duration of AF after 2 weeks, compared with the baseline values in the Sham group. In contrast, 2 weeks of RI resulted in a significant increase in AF inducibility by 1.5 fold (P < 0.05) (Fig 5B) and prolonged the duration of AF by 1.86 fold compared with the baseline values in the Model group (P < 0.05). The AF inducibility was unchanged after 2 weeks, compared with the baseline values in the RDN group (P > 0.05) (Fig 5C). RDN completely prevented RI-induced prolongation of AF duration (P < 0.05) (Fig 5D).

Bottom Line: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated.Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: A close association exists between renal impairment (RI) and atrial fibrillation (AF) occurrence. Increased activity of the sympathetic nervous system (SNS) may contribute to the development of AF associated with RI. Renal denervation (RDN) decreases central sympathetic activity.

Objective: The main objective of the study was to explore the effects of RDN on AF occurrence and its possible mechanisms in beagles with RI.

Methods: Unilateral RI was induced in beagles by embolization of small branches of the renal artery in the right kidney using gelatin sponge granules in Model (n = 6) and RDN group (n = 6). The Sham group (n = 6) underwent the same procedure, except for embolization. Then animals in RDN group underwent radiofrequency ablation of the renal sympathetic nerve. Cardiac electrophysiological parameters, blood pressure, left ventricular end-diastolic pressure, and AF inducibility were investigated. The activity of the SNS, renin-angiotensin-aldosterone system (RAAS), inflammation and atrial interstitial fibrosis were measured.

Results: Embolization of small branches of the renal artery in the right kidney led to ischemic RI. Heart rate, P wave duration and BP were increased by RI, which were prevented or attenuated by RDN. Atrial effective refractory period was shortened and AF inducibility was increased by RI, which were prevented by RDN. Antegrade Wenckebach point was shortened, atrial and ventricular rates during AF were increased by RI, which were attenuated or prevented by RDN. Levels of norepinephrine, renin and aldosterone in plasma, norepinephrine, angiotensin II, aldosterone, interleukin-6 and high sensitivity C-reactive protein in atrial tissue were elevated, and atrial interstitial fibrosis was enhanced by RI, which were attenuated by RDN.

Conclusions: RDN significantly reduced AF inducibility, prevented the atrial electrophysiological changes in a model of RI by combined reduction of sympathetic drive and RAAS activity, and inhibition of inflammation activity and fibrotic pathway in atrial tissue.

No MeSH data available.


Related in: MedlinePlus