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Weaker dental enamel explains dental decay.

Vieira AR, Gibson CW, Deeley K, Xue H, Li Y - PLoS ONE (2015)

Bottom Line: Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind.Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors.Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

ABSTRACT
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

No MeSH data available.


Related in: MedlinePlus

Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin after the creation of an artificial caries lesion.The transgenic line Het C3H/B6 is more resistant to acid demineralization in comparison to knockout mice (KO B6, KO C3H N5, KO Mix) (ANOVA; p<0.0001).
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pone.0124236.g003: Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin after the creation of an artificial caries lesion.The transgenic line Het C3H/B6 is more resistant to acid demineralization in comparison to knockout mice (KO B6, KO C3H N5, KO Mix) (ANOVA; p<0.0001).

Mentions: After the creation of an artificial caries lesion, the pattern of enamel microhardness among mouse strains is similar with levels being lower in comparison to baseline values (Fig 3). The values indicate that the dental enamel shows initial stages of demineralization. These results are similar on samples from 6-week mice (data not shown).


Weaker dental enamel explains dental decay.

Vieira AR, Gibson CW, Deeley K, Xue H, Li Y - PLoS ONE (2015)

Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin after the creation of an artificial caries lesion.The transgenic line Het C3H/B6 is more resistant to acid demineralization in comparison to knockout mice (KO B6, KO C3H N5, KO Mix) (ANOVA; p<0.0001).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401694&req=5

pone.0124236.g003: Mean enamel microhardness of 5-month old mice developed with variable amounts of amelogenin after the creation of an artificial caries lesion.The transgenic line Het C3H/B6 is more resistant to acid demineralization in comparison to knockout mice (KO B6, KO C3H N5, KO Mix) (ANOVA; p<0.0001).
Mentions: After the creation of an artificial caries lesion, the pattern of enamel microhardness among mouse strains is similar with levels being lower in comparison to baseline values (Fig 3). The values indicate that the dental enamel shows initial stages of demineralization. These results are similar on samples from 6-week mice (data not shown).

Bottom Line: Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind.Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors.Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

ABSTRACT
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

No MeSH data available.


Related in: MedlinePlus