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Weaker dental enamel explains dental decay.

Vieira AR, Gibson CW, Deeley K, Xue H, Li Y - PLoS ONE (2015)

Bottom Line: Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind.Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors.Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

ABSTRACT
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

No MeSH data available.


Related in: MedlinePlus

Mouse strains and Amelx expression levels.Western blot analysis confirms predictions from Table 1.
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pone.0124236.g001: Mouse strains and Amelx expression levels.Western blot analysis confirms predictions from Table 1.

Mentions: Transgenic mice on a wild-type (WT) background are expected to have more amelogenin protein compared to WT, and heterozygous (Amelx +/-) females should have approximately half the WT amount (Fig 1). KO and transgenic mice were mated and transgene+/KO mice expressed a single amelogenin gene [30].


Weaker dental enamel explains dental decay.

Vieira AR, Gibson CW, Deeley K, Xue H, Li Y - PLoS ONE (2015)

Mouse strains and Amelx expression levels.Western blot analysis confirms predictions from Table 1.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401694&req=5

pone.0124236.g001: Mouse strains and Amelx expression levels.Western blot analysis confirms predictions from Table 1.
Mentions: Transgenic mice on a wild-type (WT) background are expected to have more amelogenin protein compared to WT, and heterozygous (Amelx +/-) females should have approximately half the WT amount (Fig 1). KO and transgenic mice were mated and transgene+/KO mice expressed a single amelogenin gene [30].

Bottom Line: Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind.Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors.Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

ABSTRACT
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free individuals exposed to the same risk factors. In order to test the hypothesis that amount of amelogenin during enamel development can influence caries susceptibility, we generated multiple strains of mice with varying levels of available amelogenin during dental development. Mechanical tests showed that dental enamel developed with less amelogenin is "weaker" while the dental enamel of animals over-expressing amelogenin appears to be more resistant to acid dissolution.

No MeSH data available.


Related in: MedlinePlus