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An investigation of two-dimensional ultrasound carotid plaque presence and intima media thickness in middle-aged South Asian and European men living in the United kingdom.

Ghouri N, Purves D, Deans KA, Logan G, McConnachie A, Wilson J, Gill JM, Sattar N - PLoS ONE (2015)

Bottom Line: We determined whether South Asians have a difference in these ultrasound markers compared to Europeans living in the United Kingdom and whether measured risk factor(s) could account for any such differences.Physical activity, cardiorespiratory fitness, anthropometry and blood pressure were assessed, fasted blood taken for measurement of cardiometabolic risk factors and demographic and lifestyle factors recorded.Age-adjusted mean (SD) cIMT was similar in South Asians and Europeans (0.64 (0.16) mm v 0.65 (0.12) mm, p = 0.64).

View Article: PubMed Central - PubMed

Affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, United Kingdom.

ABSTRACT

Objectives: Ultrasound studies of carotid intima media thickness (cIMT) and plaques are limited in South Asians, a group at elevated cardiovascular disease (CVD) risk. We determined whether South Asians have a difference in these ultrasound markers compared to Europeans living in the United Kingdom and whether measured risk factor(s) could account for any such differences.

Methods: One hundred South Asian men, aged 40 to 70 years and 100 European men of similar age and BMI, without diagnosed CVD or diabetes, underwent carotid ultrasound for measurement of cIMT and carotid plaque presence. Physical activity, cardiorespiratory fitness, anthropometry and blood pressure were assessed, fasted blood taken for measurement of cardiometabolic risk factors and demographic and lifestyle factors recorded.

Results: Age-adjusted mean (SD) cIMT was similar in South Asians and Europeans (0.64 (0.16) mm v 0.65 (0.12) mm, p = 0.64). Plaque was present in 48 South Asians and 37 Europeans and overall, there was no age-adjusted difference between South Asian and Europeans for plaque score(odds ratio 1.49, 95% CI, 0.86-2.80, p = 0.16), however, South Asians appeared to have more plaques at a younger age than Europeans; at age 40-50 years the odds of South Asians having plaques was 2.63 (95% CI, 1.16-5.93) times that for Europeans.

Conclusions: cIMT is similar between healthy South Asian and European men. Whilst there was no overall difference in plaque presence in South Asians, there is an indication of greater plaque prevalence at younger ages--an observation requiring further investigation. Prospective studies linking plaques to CVD outcomes in South Asians are needed to investigate whether these measures help improve CVD risk prediction.

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Presence of carotid plaque by ethnicity and age*.*Percentage of participants within each category. Number of participants in each age category (South Asian, European): 40–45 (36, 30); 46–50 (23, 29); 51–55 (23,23); 56–60 (9, 10); 61–69 (9, 8)
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pone.0123317.g002: Presence of carotid plaque by ethnicity and age*.*Percentage of participants within each category. Number of participants in each age category (South Asian, European): 40–45 (36, 30); 46–50 (23, 29); 51–55 (23,23); 56–60 (9, 10); 61–69 (9, 8)

Mentions: Of interest, plaques were more prevalent in the younger South Asians, as seen in Fig 2; in 40–50 year-olds, South Asians had 2.63 (95% CI, 1.16–5.93; p = 0.019) times the odds of plaques compared to Europeans, whereas there was no evidence of a difference at older age. Further, there was a significant interaction between ethnicity and age when predicting the odds of carotid plaques; the odds of plaques increased with age for European men, while no association with age was observed in South Asian men


An investigation of two-dimensional ultrasound carotid plaque presence and intima media thickness in middle-aged South Asian and European men living in the United kingdom.

Ghouri N, Purves D, Deans KA, Logan G, McConnachie A, Wilson J, Gill JM, Sattar N - PLoS ONE (2015)

Presence of carotid plaque by ethnicity and age*.*Percentage of participants within each category. Number of participants in each age category (South Asian, European): 40–45 (36, 30); 46–50 (23, 29); 51–55 (23,23); 56–60 (9, 10); 61–69 (9, 8)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401566&req=5

pone.0123317.g002: Presence of carotid plaque by ethnicity and age*.*Percentage of participants within each category. Number of participants in each age category (South Asian, European): 40–45 (36, 30); 46–50 (23, 29); 51–55 (23,23); 56–60 (9, 10); 61–69 (9, 8)
Mentions: Of interest, plaques were more prevalent in the younger South Asians, as seen in Fig 2; in 40–50 year-olds, South Asians had 2.63 (95% CI, 1.16–5.93; p = 0.019) times the odds of plaques compared to Europeans, whereas there was no evidence of a difference at older age. Further, there was a significant interaction between ethnicity and age when predicting the odds of carotid plaques; the odds of plaques increased with age for European men, while no association with age was observed in South Asian men

Bottom Line: We determined whether South Asians have a difference in these ultrasound markers compared to Europeans living in the United Kingdom and whether measured risk factor(s) could account for any such differences.Physical activity, cardiorespiratory fitness, anthropometry and blood pressure were assessed, fasted blood taken for measurement of cardiometabolic risk factors and demographic and lifestyle factors recorded.Age-adjusted mean (SD) cIMT was similar in South Asians and Europeans (0.64 (0.16) mm v 0.65 (0.12) mm, p = 0.64).

View Article: PubMed Central - PubMed

Affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, United Kingdom.

ABSTRACT

Objectives: Ultrasound studies of carotid intima media thickness (cIMT) and plaques are limited in South Asians, a group at elevated cardiovascular disease (CVD) risk. We determined whether South Asians have a difference in these ultrasound markers compared to Europeans living in the United Kingdom and whether measured risk factor(s) could account for any such differences.

Methods: One hundred South Asian men, aged 40 to 70 years and 100 European men of similar age and BMI, without diagnosed CVD or diabetes, underwent carotid ultrasound for measurement of cIMT and carotid plaque presence. Physical activity, cardiorespiratory fitness, anthropometry and blood pressure were assessed, fasted blood taken for measurement of cardiometabolic risk factors and demographic and lifestyle factors recorded.

Results: Age-adjusted mean (SD) cIMT was similar in South Asians and Europeans (0.64 (0.16) mm v 0.65 (0.12) mm, p = 0.64). Plaque was present in 48 South Asians and 37 Europeans and overall, there was no age-adjusted difference between South Asian and Europeans for plaque score(odds ratio 1.49, 95% CI, 0.86-2.80, p = 0.16), however, South Asians appeared to have more plaques at a younger age than Europeans; at age 40-50 years the odds of South Asians having plaques was 2.63 (95% CI, 1.16-5.93) times that for Europeans.

Conclusions: cIMT is similar between healthy South Asian and European men. Whilst there was no overall difference in plaque presence in South Asians, there is an indication of greater plaque prevalence at younger ages--an observation requiring further investigation. Prospective studies linking plaques to CVD outcomes in South Asians are needed to investigate whether these measures help improve CVD risk prediction.

Show MeSH
Related in: MedlinePlus