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High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil.

Bandeira LM, Uehara SN, Asato MA, Aguena GS, Maedo CM, Benites NH, Puga MA, Rezende GR, Finotti CM, Cesar GA, Tanaka TS, Castro VO, Otsuki K, Vicente AC, Fernandes CE, Motta-Castro AR - PLoS Negl Trop Dis (2015)

Bottom Line: Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years.Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

ABSTRACT

Background: Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan.

Objective: This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV.

Study design: A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing.

Results: The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).

Conclusion: The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.

No MeSH data available.


Related in: MedlinePlus

Box plot (interquartile intervals and ranges) for the age distribution (years) of anti-HTLV-1 seropositive and anti-HTLV-1 seronegative individuals from the Japanese community of Campo Grande-MS (n = 219).Whiskers represent maximum 1.5 IQR.
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pntd.0003691.g001: Box plot (interquartile intervals and ranges) for the age distribution (years) of anti-HTLV-1 seropositive and anti-HTLV-1 seronegative individuals from the Japanese community of Campo Grande-MS (n = 219).Whiskers represent maximum 1.5 IQR.

Mentions: Risk factors for HTLV infection among the studied population are shown in Table 1. In the univariate analysis, HTLV-1 infection was associated only with age ≥ 45 years (P = 0.04). The mean age of subjects positive for HTLV-1 was 70 years, which was greater than that of 53 years for non-reactive subjects. Fig 1 shows the variation of age in individuals negative and positive for HTLV-1. Age of infected participants was concentrated in the seventh decade of life, with only two outliers representing younger infected individuals (between 40 and 60 years). However, the age of uninfected people ranged from 11 to 101 years, mainly in the range of 40 to 70 years. All infected subjects were breastfed as children; however, this risk factor was not statistically significant. Some risk factors were absent or infrequently reported in this population, such as history of tattooing, injection drug use and multiple partners.


High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil.

Bandeira LM, Uehara SN, Asato MA, Aguena GS, Maedo CM, Benites NH, Puga MA, Rezende GR, Finotti CM, Cesar GA, Tanaka TS, Castro VO, Otsuki K, Vicente AC, Fernandes CE, Motta-Castro AR - PLoS Negl Trop Dis (2015)

Box plot (interquartile intervals and ranges) for the age distribution (years) of anti-HTLV-1 seropositive and anti-HTLV-1 seronegative individuals from the Japanese community of Campo Grande-MS (n = 219).Whiskers represent maximum 1.5 IQR.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401538&req=5

pntd.0003691.g001: Box plot (interquartile intervals and ranges) for the age distribution (years) of anti-HTLV-1 seropositive and anti-HTLV-1 seronegative individuals from the Japanese community of Campo Grande-MS (n = 219).Whiskers represent maximum 1.5 IQR.
Mentions: Risk factors for HTLV infection among the studied population are shown in Table 1. In the univariate analysis, HTLV-1 infection was associated only with age ≥ 45 years (P = 0.04). The mean age of subjects positive for HTLV-1 was 70 years, which was greater than that of 53 years for non-reactive subjects. Fig 1 shows the variation of age in individuals negative and positive for HTLV-1. Age of infected participants was concentrated in the seventh decade of life, with only two outliers representing younger infected individuals (between 40 and 60 years). However, the age of uninfected people ranged from 11 to 101 years, mainly in the range of 40 to 70 years. All infected subjects were breastfed as children; however, this risk factor was not statistically significant. Some risk factors were absent or infrequently reported in this population, such as history of tattooing, injection drug use and multiple partners.

Bottom Line: Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years.Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.

View Article: PubMed Central - PubMed

Affiliation: Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

ABSTRACT

Background: Human T-lymphotropic virus type 1 (HTLV-1) has worldwide distribution and is considered endemic in many world regions, including southwestern Japan and Brazil. Japanese immigrants and their descendants have a high risk of acquiring this infection due to intense population exchange between Brazil and Japan.

Objective: This cross-sectional study aimed to estimate the prevalence of HTLV, analyze the main risk factors associated with this infection, identify the main circulating types and subtypes of HTLV in Japanese immigrants and descendants living in Campo Grande-MS (Middle-West Brazil), as well as analyze the phylogenetic relationship among isolates of HTLV.

Study design: A total of 219 individuals were interviewed and submitted to blood collection. All collected blood samples were submitted for detection of anti-HTLV-1/2 using the immunoassay ELISA and confirmed by immunoblot method. The proviral DNA of the 14 samples HTLV- 1 positive were genotyped by nucleotide sequencing.

Results: The overall prevalence of HTLV-1 was 6.8% (IC 95%: 3,5-10,2). Descriptive analysis of behavioral risk factors showed statistical association between HTLV-1 and age greater than or equal to 45 years. The proviral DNA of HTLV-1 was detected in all HTLV-1 positive samples. Of these, 14 were sequenced and classified as Cosmopolitan subtype, and 50% (7/14) belonged to subgroup A (transcontinental) and 50% (7/14) to the subgroup B (Japanese).

Conclusion: The high prevalence of HTLV-1 found evidence of the importance of early diagnosis and counseling of individuals infected with HTLV-1 for the control and prevention of the spread of this infection among Japanese immigrants and their descendants in Central Brazil.

No MeSH data available.


Related in: MedlinePlus