Limits...
Exploring the genetic signature of body size in Yucatan miniature pig.

Kim H, Song KD, Kim HJ, Park W, Kim J, Lee T, Shin DH, Kwak W, Kwon YJ, Sung S, Moon S, Lee KT, Kim N, Hong JK, Eo KY, Seo KS, Kim G, Park S, Yun CH, Kim H, Choi K, Kim J, Lee WK, Kim DK, Oh JD, Kim ES, Cho S, Lee HK, Kim TH, Kim H - PLoS ONE (2015)

Bottom Line: Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar).We found that both selections at the level of organism, and at the cellular level have occurred.Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

View Article: PubMed Central - PubMed

Affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.

ABSTRACT
Since being domesticated about 10,000-12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

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Related in: MedlinePlus

Nucleotide diversity (A and C) and cumulative average of nucleotide diversity (B) for each swine breed.Nucleotide diversity of 107-bp non-overlapping window is shown. Each pig breed is marked by a colored line; orange for wild boar, blue for Landrace, green for Yorkshire, purple for Yucatan miniature pig and yellow for Duroc.
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pone.0121732.g001: Nucleotide diversity (A and C) and cumulative average of nucleotide diversity (B) for each swine breed.Nucleotide diversity of 107-bp non-overlapping window is shown. Each pig breed is marked by a colored line; orange for wild boar, blue for Landrace, green for Yorkshire, purple for Yucatan miniature pig and yellow for Duroc.

Mentions: Nucleotide diversity of 107-bp non-overlapping window was calculated, and π value and its cumulative average for each swine breed are shown in Fig 1A and 1B. Fig 1C shows pairwise π values between YMP and other swine breeds from Fig 1A. YMP had the lowest nucleotide diversity and Wild boar had the highest nucleotide diversity among 5 swine breeds.


Exploring the genetic signature of body size in Yucatan miniature pig.

Kim H, Song KD, Kim HJ, Park W, Kim J, Lee T, Shin DH, Kwak W, Kwon YJ, Sung S, Moon S, Lee KT, Kim N, Hong JK, Eo KY, Seo KS, Kim G, Park S, Yun CH, Kim H, Choi K, Kim J, Lee WK, Kim DK, Oh JD, Kim ES, Cho S, Lee HK, Kim TH, Kim H - PLoS ONE (2015)

Nucleotide diversity (A and C) and cumulative average of nucleotide diversity (B) for each swine breed.Nucleotide diversity of 107-bp non-overlapping window is shown. Each pig breed is marked by a colored line; orange for wild boar, blue for Landrace, green for Yorkshire, purple for Yucatan miniature pig and yellow for Duroc.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401510&req=5

pone.0121732.g001: Nucleotide diversity (A and C) and cumulative average of nucleotide diversity (B) for each swine breed.Nucleotide diversity of 107-bp non-overlapping window is shown. Each pig breed is marked by a colored line; orange for wild boar, blue for Landrace, green for Yorkshire, purple for Yucatan miniature pig and yellow for Duroc.
Mentions: Nucleotide diversity of 107-bp non-overlapping window was calculated, and π value and its cumulative average for each swine breed are shown in Fig 1A and 1B. Fig 1C shows pairwise π values between YMP and other swine breeds from Fig 1A. YMP had the lowest nucleotide diversity and Wild boar had the highest nucleotide diversity among 5 swine breeds.

Bottom Line: Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar).We found that both selections at the level of organism, and at the cellular level have occurred.Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

View Article: PubMed Central - PubMed

Affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.

ABSTRACT
Since being domesticated about 10,000-12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.

Show MeSH
Related in: MedlinePlus