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Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Somatosensory and auditory cortices: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) with greyscale lines of iso-geodesic distance (mm) from the primary sensory cortex (S1 or A1). Middle column: continuous measure of geodesic distance from S1/A1. Right column: structural hierarchical level of somatosensory and auditory regions based on axonal tracer studies and cytoarchitecture in the macaque (Felleman and Van Essen, 1991; Barbas, 1986). Matching hierarchies and cortical parcellations were not available for humans. Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant. Data overlaid on inflated left hemispheres, lateral views. Rostral (R), caudal (C).
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f0050: Somatosensory and auditory cortices: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) with greyscale lines of iso-geodesic distance (mm) from the primary sensory cortex (S1 or A1). Middle column: continuous measure of geodesic distance from S1/A1. Right column: structural hierarchical level of somatosensory and auditory regions based on axonal tracer studies and cytoarchitecture in the macaque (Felleman and Van Essen, 1991; Barbas, 1986). Matching hierarchies and cortical parcellations were not available for humans. Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant. Data overlaid on inflated left hemispheres, lateral views. Rostral (R), caudal (C).

Mentions: Human data were analysed using Spearman's partial rank correlation and a linear mixed-effects model, controlling for the effect of hemisphere and the random effects of individuals (see Table 1). In agreement with the macaque data and our original hypothesis geodesic distance was significantly predicted by cortical thickness in the visual, somatosensory and auditory cortices (Figs. 6, 8 and 9). For somatosensory and auditory cortices the correlations were not as strong but were still significant (Fig. 9).


Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Somatosensory and auditory cortices: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) with greyscale lines of iso-geodesic distance (mm) from the primary sensory cortex (S1 or A1). Middle column: continuous measure of geodesic distance from S1/A1. Right column: structural hierarchical level of somatosensory and auditory regions based on axonal tracer studies and cytoarchitecture in the macaque (Felleman and Van Essen, 1991; Barbas, 1986). Matching hierarchies and cortical parcellations were not available for humans. Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant. Data overlaid on inflated left hemispheres, lateral views. Rostral (R), caudal (C).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401442&req=5

f0050: Somatosensory and auditory cortices: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) with greyscale lines of iso-geodesic distance (mm) from the primary sensory cortex (S1 or A1). Middle column: continuous measure of geodesic distance from S1/A1. Right column: structural hierarchical level of somatosensory and auditory regions based on axonal tracer studies and cytoarchitecture in the macaque (Felleman and Van Essen, 1991; Barbas, 1986). Matching hierarchies and cortical parcellations were not available for humans. Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant. Data overlaid on inflated left hemispheres, lateral views. Rostral (R), caudal (C).
Mentions: Human data were analysed using Spearman's partial rank correlation and a linear mixed-effects model, controlling for the effect of hemisphere and the random effects of individuals (see Table 1). In agreement with the macaque data and our original hypothesis geodesic distance was significantly predicted by cortical thickness in the visual, somatosensory and auditory cortices (Figs. 6, 8 and 9). For somatosensory and auditory cortices the correlations were not as strong but were still significant (Fig. 9).

Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus