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Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Visual cortex: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) for the visual cortex with greyscale lines of iso-geodesic distance (mm) from the primary visual cortex (V1). Middle column: continuous measure of geodesic distance from V1. Right column: structural hierarchical level of visual regions based on axonal tracer studies in the macaque (Felleman and Van Essen, 1991) and functional hierarchical level of visual regions based on fMRI in the humans (Grill-Spector and Malach, 2004). Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant (p < 0.001). Data overlaid on inflated left hemispheres, lateral and medial views. Rostral (R), caudal (C).
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f0045: Visual cortex: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) for the visual cortex with greyscale lines of iso-geodesic distance (mm) from the primary visual cortex (V1). Middle column: continuous measure of geodesic distance from V1. Right column: structural hierarchical level of visual regions based on axonal tracer studies in the macaque (Felleman and Van Essen, 1991) and functional hierarchical level of visual regions based on fMRI in the humans (Grill-Spector and Malach, 2004). Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant (p < 0.001). Data overlaid on inflated left hemispheres, lateral and medial views. Rostral (R), caudal (C).


Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Visual cortex: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) for the visual cortex with greyscale lines of iso-geodesic distance (mm) from the primary visual cortex (V1). Middle column: continuous measure of geodesic distance from V1. Right column: structural hierarchical level of visual regions based on axonal tracer studies in the macaque (Felleman and Van Essen, 1991) and functional hierarchical level of visual regions based on fMRI in the humans (Grill-Spector and Malach, 2004). Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant (p < 0.001). Data overlaid on inflated left hemispheres, lateral and medial views. Rostral (R), caudal (C).
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401442&req=5

f0045: Visual cortex: cortical thickness, geodesic distance and hierarchical level for a single macaque and human. Left column: folding-corrected cortical thickness (mm) for the visual cortex with greyscale lines of iso-geodesic distance (mm) from the primary visual cortex (V1). Middle column: continuous measure of geodesic distance from V1. Right column: structural hierarchical level of visual regions based on axonal tracer studies in the macaque (Felleman and Van Essen, 1991) and functional hierarchical level of visual regions based on fMRI in the humans (Grill-Spector and Malach, 2004). Correlations between cortical thickness, geodesic distance and hierarchical level are highly significant (p < 0.001). Data overlaid on inflated left hemispheres, lateral and medial views. Rostral (R), caudal (C).
Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus