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Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus

Macaque cortical thickness and cytoarchitecture. MRI thickness—corrected for folding—against laminar differentiation type (rs = − 0.39, p < 0.001). Laminar differentiation type is a cytoarchitectural ranking scale, with 6-layered primary sensory cortex having type 8, while less well differentiated cortical regions are given progressively lower rankings (Barbas, 1986; Barbas and Rempel-Clower, 1997; Dombrowski et al., 2001).
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f0025: Macaque cortical thickness and cytoarchitecture. MRI thickness—corrected for folding—against laminar differentiation type (rs = − 0.39, p < 0.001). Laminar differentiation type is a cytoarchitectural ranking scale, with 6-layered primary sensory cortex having type 8, while less well differentiated cortical regions are given progressively lower rankings (Barbas, 1986; Barbas and Rempel-Clower, 1997; Dombrowski et al., 2001).

Mentions: Regional laminar differentiation data were compared with folding-corrected, MRI-derived cortical thickness values using Spearman's partial rank correlation controlling for the effect of hemisphere. In agreement with our hypothesis, cortical thickness correlated negatively with laminar differentiation type (rs = − 0.39, p < 0.001)(Fig. 4).


Cortical thickness gradients in structural hierarchies.

Wagstyl K, Ronan L, Goodyer IM, Fletcher PC - Neuroimage (2015)

Macaque cortical thickness and cytoarchitecture. MRI thickness—corrected for folding—against laminar differentiation type (rs = − 0.39, p < 0.001). Laminar differentiation type is a cytoarchitectural ranking scale, with 6-layered primary sensory cortex having type 8, while less well differentiated cortical regions are given progressively lower rankings (Barbas, 1986; Barbas and Rempel-Clower, 1997; Dombrowski et al., 2001).
© Copyright Policy - CC BY
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4401442&req=5

f0025: Macaque cortical thickness and cytoarchitecture. MRI thickness—corrected for folding—against laminar differentiation type (rs = − 0.39, p < 0.001). Laminar differentiation type is a cytoarchitectural ranking scale, with 6-layered primary sensory cortex having type 8, while less well differentiated cortical regions are given progressively lower rankings (Barbas, 1986; Barbas and Rempel-Clower, 1997; Dombrowski et al., 2001).
Mentions: Regional laminar differentiation data were compared with folding-corrected, MRI-derived cortical thickness values using Spearman's partial rank correlation controlling for the effect of hemisphere. In agreement with our hypothesis, cortical thickness correlated negatively with laminar differentiation type (rs = − 0.39, p < 0.001)(Fig. 4).

Bottom Line: Our results suggest that an easily measurable macroscopic brain parameter, namely, cortical thickness, is systematically related to cytoarchitecture and to the structural hierarchical organisation of the cortex.We argue that the measurement of cortical thickness gradients may become an important way to develop our understanding of brain structure-function relationships.The identification of alterations in such gradients may complement the observation of regionally localised cortical thickness changes in our understanding of normal development and neuropsychiatric illnesses.

View Article: PubMed Central - PubMed

Affiliation: Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 3EB, UK. Electronic address: kw350@cam.ac.uk.

No MeSH data available.


Related in: MedlinePlus