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A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.


Experiment 3: Activity profiles of left (a, c) and right (b, d) phF5c plotted separately for runs with fixation to the left (a, b) and right of target (c, d). Red outlines indicate regions contralateral to the target, i.e., where the actual grasping takes place in the contralateral hemifield. Vertical bars indicate SE across subjects. The three-way interaction between factors person, action, and fixation position was significant for right phF5c (F1,17 = 17.02, p < 0.001), but not left phF5c (F1,17 = 0.04, p > 0.8). The two-way interaction between action and person factors was significant in all four panels: F1,17 = 6.2, p < 0.025 (a), F1,17 = 35, p < 0.001 (b), F1,17 = 11.3, p < 0.005 (c) and F1,17 = 10.4, p < 0.005 (d), but the response to static hand was strongest in panel B.
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f0045: Experiment 3: Activity profiles of left (a, c) and right (b, d) phF5c plotted separately for runs with fixation to the left (a, b) and right of target (c, d). Red outlines indicate regions contralateral to the target, i.e., where the actual grasping takes place in the contralateral hemifield. Vertical bars indicate SE across subjects. The three-way interaction between factors person, action, and fixation position was significant for right phF5c (F1,17 = 17.02, p < 0.001), but not left phF5c (F1,17 = 0.04, p > 0.8). The two-way interaction between action and person factors was significant in all four panels: F1,17 = 6.2, p < 0.025 (a), F1,17 = 35, p < 0.001 (b), F1,17 = 11.3, p < 0.005 (c) and F1,17 = 10.4, p < 0.005 (d), but the response to static hand was strongest in panel B.

Mentions: Thus far, we have presented interactions between action and person in Experiments 3 & 4 by pooling the data obtained with the two fixation points. However, if phF5c is sensitive to the actual grasping, the activity of the phF5c profiles should depend on the fixation point position. Hence we computed the profiles of left and right phF5c analyzing the runs for the two fixation point positions separately (Fig. 9). A three-way ANOVAs with fixation side, action and person as factors revealed a significant 3-way interaction (F1,17 = 17.02, p < 0.001) for the right site, but not the left (F1,17 = 0.04, p > 0.80). Thus the interaction between action and person, characteristic of phF5c, depends more on fixation position in the right hemisphere than in the left.


A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Experiment 3: Activity profiles of left (a, c) and right (b, d) phF5c plotted separately for runs with fixation to the left (a, b) and right of target (c, d). Red outlines indicate regions contralateral to the target, i.e., where the actual grasping takes place in the contralateral hemifield. Vertical bars indicate SE across subjects. The three-way interaction between factors person, action, and fixation position was significant for right phF5c (F1,17 = 17.02, p < 0.001), but not left phF5c (F1,17 = 0.04, p > 0.8). The two-way interaction between action and person factors was significant in all four panels: F1,17 = 6.2, p < 0.025 (a), F1,17 = 35, p < 0.001 (b), F1,17 = 11.3, p < 0.005 (c) and F1,17 = 10.4, p < 0.005 (d), but the response to static hand was strongest in panel B.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401441&req=5

f0045: Experiment 3: Activity profiles of left (a, c) and right (b, d) phF5c plotted separately for runs with fixation to the left (a, b) and right of target (c, d). Red outlines indicate regions contralateral to the target, i.e., where the actual grasping takes place in the contralateral hemifield. Vertical bars indicate SE across subjects. The three-way interaction between factors person, action, and fixation position was significant for right phF5c (F1,17 = 17.02, p < 0.001), but not left phF5c (F1,17 = 0.04, p > 0.8). The two-way interaction between action and person factors was significant in all four panels: F1,17 = 6.2, p < 0.025 (a), F1,17 = 35, p < 0.001 (b), F1,17 = 11.3, p < 0.005 (c) and F1,17 = 10.4, p < 0.005 (d), but the response to static hand was strongest in panel B.
Mentions: Thus far, we have presented interactions between action and person in Experiments 3 & 4 by pooling the data obtained with the two fixation points. However, if phF5c is sensitive to the actual grasping, the activity of the phF5c profiles should depend on the fixation point position. Hence we computed the profiles of left and right phF5c analyzing the runs for the two fixation point positions separately (Fig. 9). A three-way ANOVAs with fixation side, action and person as factors revealed a significant 3-way interaction (F1,17 = 17.02, p < 0.001) for the right site, but not the left (F1,17 = 0.04, p > 0.80). Thus the interaction between action and person, characteristic of phF5c, depends more on fixation position in the right hemisphere than in the left.

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.