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A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.


Experiment 4: a–b: flatmaps showing locations of the local maxima of the interaction in left (a) and right (b) PMv; c: plot of differential activation (in % of average activity) for person acting (blue) and hand grasping (green) as a function of frame rate in left (dashed lines) and right (solid lines) phF5c; d–e: activity profile for 20 fr/s in left (d) and right (e) phF5c. Vertical bars in c–e: SE across subjects. Colored squares in a: yellow center of the a priori ROI (− 48, 0, 48) white: LM at 14 fr/s: − 52, 0, 50, t = 2.4, p < 0.02; − 44, 2, 50, t = 2.1, p < 0.03; pink: LM at 20 fr/s: − 40, − 2 36, t = 2, p < 0.04; blue : LM at 28 fr/s − 44, 0, 46, t = 2.9, p < 0.008; − 48, 2, 50, t = 2.5, p < 0.01; colored squares in b: yellow: center of the ROI (48, 0, 48); white LM at 14 fr/s: 50, − 4, 48, t = 2;4, p < 0.02; 38, − 2, 36 t = 2.1, p < 0.03; 42, 2, 52, t = 2.0, p < 0.04; pink: LM at 20 fr/s: 44, − 2, 48, t = 3.7, p < 0.003; blue: LM at 28 fr/s: 46, 0, 40, t = 2.8, p < 0.008. The plots of c–e are based on the 8 most significant voxels after SVC with 1.3 < t < 2.4 (left) and 0.85 < t < 3 (right) for 14 fr/s, 1.3 < t < 2 (left) and 2.6 < t < 3.7 (right) for 20 fr/s, 2.3 < t < 2.9 (left) and 1.6 < t < 2.8 (right) for 28 fr/s.
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f0040: Experiment 4: a–b: flatmaps showing locations of the local maxima of the interaction in left (a) and right (b) PMv; c: plot of differential activation (in % of average activity) for person acting (blue) and hand grasping (green) as a function of frame rate in left (dashed lines) and right (solid lines) phF5c; d–e: activity profile for 20 fr/s in left (d) and right (e) phF5c. Vertical bars in c–e: SE across subjects. Colored squares in a: yellow center of the a priori ROI (− 48, 0, 48) white: LM at 14 fr/s: − 52, 0, 50, t = 2.4, p < 0.02; − 44, 2, 50, t = 2.1, p < 0.03; pink: LM at 20 fr/s: − 40, − 2 36, t = 2, p < 0.04; blue : LM at 28 fr/s − 44, 0, 46, t = 2.9, p < 0.008; − 48, 2, 50, t = 2.5, p < 0.01; colored squares in b: yellow: center of the ROI (48, 0, 48); white LM at 14 fr/s: 50, − 4, 48, t = 2;4, p < 0.02; 38, − 2, 36 t = 2.1, p < 0.03; 42, 2, 52, t = 2.0, p < 0.04; pink: LM at 20 fr/s: 44, − 2, 48, t = 3.7, p < 0.003; blue: LM at 28 fr/s: 46, 0, 40, t = 2.8, p < 0.008. The plots of c–e are based on the 8 most significant voxels after SVC with 1.3 < t < 2.4 (left) and 0.85 < t < 3 (right) for 14 fr/s, 1.3 < t < 2 (left) and 2.6 < t < 3.7 (right) for 20 fr/s, 2.3 < t < 2.9 (left) and 1.6 < t < 2.8 (right) for 28 fr/s.

Mentions: A random effects analysis yielded significant (after SVC) local maxima (LM) for each frame rate in LH (− 52, 0, 50, t = 2.4, p < 0.02; − 40, − 2, 46, t = 2.1, p < 0.04; and − 44, 0, 46, t = 2.9, p < 0.008, Fig. 8a), and RH (50, − 4, 48, t = 2.4, p < 0.02; 44, − 2, 48, t = 3.7, p < 0.002 and 46, 0, 40, t = 2.8, p < .008; Fig. 8b), although not all LM remained significant after correction for 3 tests on a single a priori ROI. The number of significant voxels was much greater for 20 fr/s in RH (46 voxels compared to 4 and 3 voxels at 14 and 28 fr/s) and for 28 fr/s in LH (9 voxels compared to 5 and 2 voxels at 14 and 20 fr/s). The number of voxels reaching significance also confirmed that the interaction was stronger on the right than the left. The differential activation, relative to static control, for acting-person and grasping-hand conditions increases with frame rate, more so for acting-person than grasping-hand (Fig. 8c). The interaction (distance between differential activations of person and hand) is relatively invariant for frame rate in both hemispheres, with a broad optimum at 20/s (Figs. 8d, e). Experiment 4 shows that, if anything, the interaction is stronger at faster frame rates than that used in Experiment 3, explaining the weaker activation in Experiment 3 compared to 1 (Fig. 3). It also generalizes the results of the previous experiment with respect to the identification of left and right phF5c to another low-level visual feature: motion speed.


A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Experiment 4: a–b: flatmaps showing locations of the local maxima of the interaction in left (a) and right (b) PMv; c: plot of differential activation (in % of average activity) for person acting (blue) and hand grasping (green) as a function of frame rate in left (dashed lines) and right (solid lines) phF5c; d–e: activity profile for 20 fr/s in left (d) and right (e) phF5c. Vertical bars in c–e: SE across subjects. Colored squares in a: yellow center of the a priori ROI (− 48, 0, 48) white: LM at 14 fr/s: − 52, 0, 50, t = 2.4, p < 0.02; − 44, 2, 50, t = 2.1, p < 0.03; pink: LM at 20 fr/s: − 40, − 2 36, t = 2, p < 0.04; blue : LM at 28 fr/s − 44, 0, 46, t = 2.9, p < 0.008; − 48, 2, 50, t = 2.5, p < 0.01; colored squares in b: yellow: center of the ROI (48, 0, 48); white LM at 14 fr/s: 50, − 4, 48, t = 2;4, p < 0.02; 38, − 2, 36 t = 2.1, p < 0.03; 42, 2, 52, t = 2.0, p < 0.04; pink: LM at 20 fr/s: 44, − 2, 48, t = 3.7, p < 0.003; blue: LM at 28 fr/s: 46, 0, 40, t = 2.8, p < 0.008. The plots of c–e are based on the 8 most significant voxels after SVC with 1.3 < t < 2.4 (left) and 0.85 < t < 3 (right) for 14 fr/s, 1.3 < t < 2 (left) and 2.6 < t < 3.7 (right) for 20 fr/s, 2.3 < t < 2.9 (left) and 1.6 < t < 2.8 (right) for 28 fr/s.
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f0040: Experiment 4: a–b: flatmaps showing locations of the local maxima of the interaction in left (a) and right (b) PMv; c: plot of differential activation (in % of average activity) for person acting (blue) and hand grasping (green) as a function of frame rate in left (dashed lines) and right (solid lines) phF5c; d–e: activity profile for 20 fr/s in left (d) and right (e) phF5c. Vertical bars in c–e: SE across subjects. Colored squares in a: yellow center of the a priori ROI (− 48, 0, 48) white: LM at 14 fr/s: − 52, 0, 50, t = 2.4, p < 0.02; − 44, 2, 50, t = 2.1, p < 0.03; pink: LM at 20 fr/s: − 40, − 2 36, t = 2, p < 0.04; blue : LM at 28 fr/s − 44, 0, 46, t = 2.9, p < 0.008; − 48, 2, 50, t = 2.5, p < 0.01; colored squares in b: yellow: center of the ROI (48, 0, 48); white LM at 14 fr/s: 50, − 4, 48, t = 2;4, p < 0.02; 38, − 2, 36 t = 2.1, p < 0.03; 42, 2, 52, t = 2.0, p < 0.04; pink: LM at 20 fr/s: 44, − 2, 48, t = 3.7, p < 0.003; blue: LM at 28 fr/s: 46, 0, 40, t = 2.8, p < 0.008. The plots of c–e are based on the 8 most significant voxels after SVC with 1.3 < t < 2.4 (left) and 0.85 < t < 3 (right) for 14 fr/s, 1.3 < t < 2 (left) and 2.6 < t < 3.7 (right) for 20 fr/s, 2.3 < t < 2.9 (left) and 1.6 < t < 2.8 (right) for 28 fr/s.
Mentions: A random effects analysis yielded significant (after SVC) local maxima (LM) for each frame rate in LH (− 52, 0, 50, t = 2.4, p < 0.02; − 40, − 2, 46, t = 2.1, p < 0.04; and − 44, 0, 46, t = 2.9, p < 0.008, Fig. 8a), and RH (50, − 4, 48, t = 2.4, p < 0.02; 44, − 2, 48, t = 3.7, p < 0.002 and 46, 0, 40, t = 2.8, p < .008; Fig. 8b), although not all LM remained significant after correction for 3 tests on a single a priori ROI. The number of significant voxels was much greater for 20 fr/s in RH (46 voxels compared to 4 and 3 voxels at 14 and 28 fr/s) and for 28 fr/s in LH (9 voxels compared to 5 and 2 voxels at 14 and 20 fr/s). The number of voxels reaching significance also confirmed that the interaction was stronger on the right than the left. The differential activation, relative to static control, for acting-person and grasping-hand conditions increases with frame rate, more so for acting-person than grasping-hand (Fig. 8c). The interaction (distance between differential activations of person and hand) is relatively invariant for frame rate in both hemispheres, with a broad optimum at 20/s (Figs. 8d, e). Experiment 4 shows that, if anything, the interaction is stronger at faster frame rates than that used in Experiment 3, explaining the weaker activation in Experiment 3 compared to 1 (Fig. 3). It also generalizes the results of the previous experiment with respect to the identification of left and right phF5c to another low-level visual feature: motion speed.

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.