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A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.


Related in: MedlinePlus

a, c: Statistical parametric maps (SPMs) showing in color the voxels activated in the subtraction acting person vs controls (blue outline), grasping hand vs controls (green), and the interaction, i.e. the difference between the previous subtractions (yellow) obtained in Experiment 1 (a) and Experiment 3 (c), shown on the flatmaps of the anterior portions of left (LH) and right (RH) hemispheres. Thresholds: p < 0.001 uncorrected in a and interaction in c, p < 0.01 uncorrected blue outline in c. Local maxima in c: 1: LH1: − 44, − 10, 56, 12 voxels, 2: LH2: − 56, 6, 38, 27 voxels; 3: LH3: − 32, − 10, 40, 29 voxels; 4: RH : 48, 0, 48, 109 voxels; notice that LH3 is located in the posterior branch of PCSi which folds behind the PCG in 3D; yellow dots encircled by black: local maxima of interaction in Experiment 4 averaging over frame rate (uncorrected: − 40, 0, 36, t = 4.77, p < 0.001 and 46, − 4, 44, t = 3.32, p < 0.003); b, d: differential activity (as % of fixation baseline) evoked by acting person vs controls (blue) and grasping hand vs controls (green) obtained in Experiment 1 (b) and Experiment 3 (d), plotted from dorsal to ventral for the miniROIs, shown in white in RH of a, c. Vertical bars SE. The difference between differential activity for acting person and grasping hand was significant in bins 8–10 in b (paired t tests p < 0.05) and bins 7–11 in d (p < 0.05 in post hoc t-tests following interaction in a 2 × 17 two way ANOVA, F16, 17 = 2.25, p < 0.005).
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f0020: a, c: Statistical parametric maps (SPMs) showing in color the voxels activated in the subtraction acting person vs controls (blue outline), grasping hand vs controls (green), and the interaction, i.e. the difference between the previous subtractions (yellow) obtained in Experiment 1 (a) and Experiment 3 (c), shown on the flatmaps of the anterior portions of left (LH) and right (RH) hemispheres. Thresholds: p < 0.001 uncorrected in a and interaction in c, p < 0.01 uncorrected blue outline in c. Local maxima in c: 1: LH1: − 44, − 10, 56, 12 voxels, 2: LH2: − 56, 6, 38, 27 voxels; 3: LH3: − 32, − 10, 40, 29 voxels; 4: RH : 48, 0, 48, 109 voxels; notice that LH3 is located in the posterior branch of PCSi which folds behind the PCG in 3D; yellow dots encircled by black: local maxima of interaction in Experiment 4 averaging over frame rate (uncorrected: − 40, 0, 36, t = 4.77, p < 0.001 and 46, − 4, 44, t = 3.32, p < 0.003); b, d: differential activity (as % of fixation baseline) evoked by acting person vs controls (blue) and grasping hand vs controls (green) obtained in Experiment 1 (b) and Experiment 3 (d), plotted from dorsal to ventral for the miniROIs, shown in white in RH of a, c. Vertical bars SE. The difference between differential activity for acting person and grasping hand was significant in bins 8–10 in b (paired t tests p < 0.05) and bins 7–11 in d (p < 0.05 in post hoc t-tests following interaction in a 2 × 17 two way ANOVA, F16, 17 = 2.25, p < 0.005).

Mentions: The precentral sulcus (PCS) is subdivided into two parts (Germann et al., 2005) by a horizontal ridge at the level of the middle frontal gyrus (MFG): superior (PCSs) and inferior (PCSi) parts, connecting to the superior frontal sulcus (SFS) and inferior frontal sulcus (IFS), respectively (Fig. 4a). The right interaction region (yellow) is located at the junction of the posterior PCSi bank and the lower bank of the ridge. Above and below this interaction region, additional activations were present during the observation of both the grasping hand (green) and the acting person (blue outline). In the left hemisphere (LH) only a dorsal region was activated by both the acting person and grasping hand (Fig. 4a). Even lowering the threshold failed to reveal any interaction in the left hemisphere.


A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

a, c: Statistical parametric maps (SPMs) showing in color the voxels activated in the subtraction acting person vs controls (blue outline), grasping hand vs controls (green), and the interaction, i.e. the difference between the previous subtractions (yellow) obtained in Experiment 1 (a) and Experiment 3 (c), shown on the flatmaps of the anterior portions of left (LH) and right (RH) hemispheres. Thresholds: p < 0.001 uncorrected in a and interaction in c, p < 0.01 uncorrected blue outline in c. Local maxima in c: 1: LH1: − 44, − 10, 56, 12 voxels, 2: LH2: − 56, 6, 38, 27 voxels; 3: LH3: − 32, − 10, 40, 29 voxels; 4: RH : 48, 0, 48, 109 voxels; notice that LH3 is located in the posterior branch of PCSi which folds behind the PCG in 3D; yellow dots encircled by black: local maxima of interaction in Experiment 4 averaging over frame rate (uncorrected: − 40, 0, 36, t = 4.77, p < 0.001 and 46, − 4, 44, t = 3.32, p < 0.003); b, d: differential activity (as % of fixation baseline) evoked by acting person vs controls (blue) and grasping hand vs controls (green) obtained in Experiment 1 (b) and Experiment 3 (d), plotted from dorsal to ventral for the miniROIs, shown in white in RH of a, c. Vertical bars SE. The difference between differential activity for acting person and grasping hand was significant in bins 8–10 in b (paired t tests p < 0.05) and bins 7–11 in d (p < 0.05 in post hoc t-tests following interaction in a 2 × 17 two way ANOVA, F16, 17 = 2.25, p < 0.005).
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

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f0020: a, c: Statistical parametric maps (SPMs) showing in color the voxels activated in the subtraction acting person vs controls (blue outline), grasping hand vs controls (green), and the interaction, i.e. the difference between the previous subtractions (yellow) obtained in Experiment 1 (a) and Experiment 3 (c), shown on the flatmaps of the anterior portions of left (LH) and right (RH) hemispheres. Thresholds: p < 0.001 uncorrected in a and interaction in c, p < 0.01 uncorrected blue outline in c. Local maxima in c: 1: LH1: − 44, − 10, 56, 12 voxels, 2: LH2: − 56, 6, 38, 27 voxels; 3: LH3: − 32, − 10, 40, 29 voxels; 4: RH : 48, 0, 48, 109 voxels; notice that LH3 is located in the posterior branch of PCSi which folds behind the PCG in 3D; yellow dots encircled by black: local maxima of interaction in Experiment 4 averaging over frame rate (uncorrected: − 40, 0, 36, t = 4.77, p < 0.001 and 46, − 4, 44, t = 3.32, p < 0.003); b, d: differential activity (as % of fixation baseline) evoked by acting person vs controls (blue) and grasping hand vs controls (green) obtained in Experiment 1 (b) and Experiment 3 (d), plotted from dorsal to ventral for the miniROIs, shown in white in RH of a, c. Vertical bars SE. The difference between differential activity for acting person and grasping hand was significant in bins 8–10 in b (paired t tests p < 0.05) and bins 7–11 in d (p < 0.05 in post hoc t-tests following interaction in a 2 × 17 two way ANOVA, F16, 17 = 2.25, p < 0.005).
Mentions: The precentral sulcus (PCS) is subdivided into two parts (Germann et al., 2005) by a horizontal ridge at the level of the middle frontal gyrus (MFG): superior (PCSs) and inferior (PCSi) parts, connecting to the superior frontal sulcus (SFS) and inferior frontal sulcus (IFS), respectively (Fig. 4a). The right interaction region (yellow) is located at the junction of the posterior PCSi bank and the lower bank of the ridge. Above and below this interaction region, additional activations were present during the observation of both the grasping hand (green) and the acting person (blue outline). In the left hemisphere (LH) only a dorsal region was activated by both the acting person and grasping hand (Fig. 4a). Even lowering the threshold failed to reveal any interaction in the left hemisphere.

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.


Related in: MedlinePlus