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A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.


a: Experiment S2: Activity profiles of right phF5c (109 voxels from Experiment 3) in 7 subjects common to Experiments 3 (only runs with right fixation) and S2. Same color code as in Fig. 5. The interaction proved significant for fixation down (Experiment 3, F1,6 = 25, p < 0.005, left), but not for fixation up (Experiment S2, F1,6 = 0.2, p > 0.6, right). b: Experiment S3. Activity profiles of 8 most significant voxels after SVC in the a priori ROI derived from Experiment 3, for the fixation runs (left, ‘yes’, orange hatching) and no-fixation runs (middle & right, ‘no’, yellow hatching). For the fixation runs the LM (50, − 4, 50, t = 2.25, p < 0.03) was located within 5 mm of the LM in Experiment 4, for non-fixation runs the LM (46, 10, 46, t = 2.09, p < 0.04) was located at more than 10 mm from the LM in Experiment 4. The visual response to the person acting was significant in the fixation runs (‘yes’, paired t test with fixation t8 = 2.5, p < 0.04), but not the non-fixation runs (‘no’, t8 = 0.27, p > 07 for 50, − 4, 50, and t8 = 0.15 p > 0.7 for 46, 10, 46). Vertical bars indicate SE across subjects.
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f0050: a: Experiment S2: Activity profiles of right phF5c (109 voxels from Experiment 3) in 7 subjects common to Experiments 3 (only runs with right fixation) and S2. Same color code as in Fig. 5. The interaction proved significant for fixation down (Experiment 3, F1,6 = 25, p < 0.005, left), but not for fixation up (Experiment S2, F1,6 = 0.2, p > 0.6, right). b: Experiment S3. Activity profiles of 8 most significant voxels after SVC in the a priori ROI derived from Experiment 3, for the fixation runs (left, ‘yes’, orange hatching) and no-fixation runs (middle & right, ‘no’, yellow hatching). For the fixation runs the LM (50, − 4, 50, t = 2.25, p < 0.03) was located within 5 mm of the LM in Experiment 4, for non-fixation runs the LM (46, 10, 46, t = 2.09, p < 0.04) was located at more than 10 mm from the LM in Experiment 4. The visual response to the person acting was significant in the fixation runs (‘yes’, paired t test with fixation t8 = 2.5, p < 0.04), but not the non-fixation runs (‘no’, t8 = 0.27, p > 07 for 50, − 4, 50, and t8 = 0.15 p > 0.7 for 46, 10, 46). Vertical bars indicate SE across subjects.

Mentions: To confirm the dependence of right phF5c on fixation position, we moved the fixation point 2° higher (Fig. 1d) in Experiment S2. The change in fixation point position had a clear effect on right phF5c, with the interaction vanishing when the fixation point was raised (Fig. 10a). The 3-way interaction (action × person × fixation position) showed a trend towards significance (F1,6 = 2.7, p = 0.1).


A human homologue of monkey F5c.

Ferri S, Peeters R, Nelissen K, Vanduffel W, Rizzolatti G, Orban GA - Neuroimage (2015)

a: Experiment S2: Activity profiles of right phF5c (109 voxels from Experiment 3) in 7 subjects common to Experiments 3 (only runs with right fixation) and S2. Same color code as in Fig. 5. The interaction proved significant for fixation down (Experiment 3, F1,6 = 25, p < 0.005, left), but not for fixation up (Experiment S2, F1,6 = 0.2, p > 0.6, right). b: Experiment S3. Activity profiles of 8 most significant voxels after SVC in the a priori ROI derived from Experiment 3, for the fixation runs (left, ‘yes’, orange hatching) and no-fixation runs (middle & right, ‘no’, yellow hatching). For the fixation runs the LM (50, − 4, 50, t = 2.25, p < 0.03) was located within 5 mm of the LM in Experiment 4, for non-fixation runs the LM (46, 10, 46, t = 2.09, p < 0.04) was located at more than 10 mm from the LM in Experiment 4. The visual response to the person acting was significant in the fixation runs (‘yes’, paired t test with fixation t8 = 2.5, p < 0.04), but not the non-fixation runs (‘no’, t8 = 0.27, p > 07 for 50, − 4, 50, and t8 = 0.15 p > 0.7 for 46, 10, 46). Vertical bars indicate SE across subjects.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4401441&req=5

f0050: a: Experiment S2: Activity profiles of right phF5c (109 voxels from Experiment 3) in 7 subjects common to Experiments 3 (only runs with right fixation) and S2. Same color code as in Fig. 5. The interaction proved significant for fixation down (Experiment 3, F1,6 = 25, p < 0.005, left), but not for fixation up (Experiment S2, F1,6 = 0.2, p > 0.6, right). b: Experiment S3. Activity profiles of 8 most significant voxels after SVC in the a priori ROI derived from Experiment 3, for the fixation runs (left, ‘yes’, orange hatching) and no-fixation runs (middle & right, ‘no’, yellow hatching). For the fixation runs the LM (50, − 4, 50, t = 2.25, p < 0.03) was located within 5 mm of the LM in Experiment 4, for non-fixation runs the LM (46, 10, 46, t = 2.09, p < 0.04) was located at more than 10 mm from the LM in Experiment 4. The visual response to the person acting was significant in the fixation runs (‘yes’, paired t test with fixation t8 = 2.5, p < 0.04), but not the non-fixation runs (‘no’, t8 = 0.27, p > 07 for 50, − 4, 50, and t8 = 0.15 p > 0.7 for 46, 10, 46). Vertical bars indicate SE across subjects.
Mentions: To confirm the dependence of right phF5c on fixation position, we moved the fixation point 2° higher (Fig. 1d) in Experiment S2. The change in fixation point position had a clear effect on right phF5c, with the interaction vanishing when the fixation point was raised (Fig. 10a). The 3-way interaction (action × person × fixation position) showed a trend towards significance (F1,6 = 2.7, p = 0.1).

Bottom Line: By presenting the two grasping actions (actor, hand) and varying the low level visual characteristics, we localized a putative human homologue of area F5c (phF5c) in the inferior part of precentral sulcus, bilaterally.In contrast to monkey F5c, phF5c is asymmetric, with a right-sided bias, and is activated more strongly during the observation of the later stages of grasping when the hand is close to the object.The latter characteristic might be related to the emergence, in humans, of the capacity to precisely copy motor acts performed by others, and thus imitation.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience, University of Parma, Parma, Italy.

No MeSH data available.