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Social cognitive and neurocognitive deficits in inpatients with unilateral thalamic lesions - pilot study.

Wilkos E, Brown TJ, Slawinska K, Kucharska KA - Neuropsychiatr Dis Treat (2015)

Bottom Line: Furthermore, compared to healthy controls, patients showed significantly delayed recognition of "happiness" in EmoDiff40 and significantly worse performance on Reading the Mind in the Eyes Test, revised version II.Neuropsychological assessment demonstrated some statistically significant deficits in learning and remembering both verbal and visual material, long-term information storing, problem solving, and executive functions such as verbal fluency.Further research is needed to increase understanding about diagnosis, early treatment, and prognosis of patients with thalamic lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroses, Personality and Eating Disorders Institute of Psychiatry and Neurology, Warsaw, Poland.

ABSTRACT

Background: The essential role of the thalamus in neurocognitive processes has been well documented. In contrast, relatively little is known about its involvement in social cognitive processes such as recognition of emotion, mentalizing, or empathy.

The aim of the study: This study was designed to compare the performance of eight patients (five males, three females, mean age ± SD: 63.7±7.9 years) at early stage of unilateral thalamic lesions and eleven healthy controls (six males, five females, 49.6±12.2 years) in neurocognitive tests (CogState Battery: Groton Maze Learning Test, GML; Groton Maze Learning Test-Delayed Recall, GML-DR; Detection Task, DT; Identification Task, IT; One Card Learning Task, OCLT; One Back Task, OBT; Two Back Task, TBT; Set-Shifting Task, S-ST) and other well-known tests (Benton Visual Retention Test, BVRT; California Verbal Learning Test, CVLT; The Rey-Osterrieth Complex Figure Test, ROCF; Trail Making Test, TMT part A and B; Color - Word Stroop Task, CWST; Verbal Fluency Test, VFT), and social cognitive tasks (The Penn Emotion Recognition Test, ER40; Penn Emotion Discrimination Task, EmoDiff40; The Penn Emotional Acuity Test, PEAT40; Reading the Mind in the Eyes Test, revised version II; Toronto Alexithymia Scale, TAS-20).

Methods: Thalamic-damaged subjects were included if they experienced a single-episode ischemic stroke localized in right or left thalamus. The patients were examined at 3 weeks after the stroke onset. All were right handed. In addition, the following clinical scales were used: the Mini-Mental State Examination (MMSE), Spielberger State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI II). An inclusion criteria was a minimum score of 23/30 in MMSE.

Results: Compared with the healthy controls, patients revealed significantly lower scores in CVLT, GML-DR, and VFT. Furthermore, compared to healthy controls, patients showed significantly delayed recognition of "happiness" in EmoDiff40 and significantly worse performance on Reading the Mind in the Eyes Test, revised version II. Neuropsychological assessment demonstrated some statistically significant deficits in learning and remembering both verbal and visual material, long-term information storing, problem solving, and executive functions such as verbal fluency.

Conclusion: Patients at early stage of unilateral thalamic stroke showed both neurocognitive and social cognitive deficits. Further research is needed to increase understanding about diagnosis, early treatment, and prognosis of patients with thalamic lesions.

No MeSH data available.


Related in: MedlinePlus

Comparison of average execution times: Groton Maze Learning Test and Penn Emotion Discrimination Tasks.Notes: In the graphs are given the value of the average rank results, which proved to be significant.
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f2-ndt-11-1031: Comparison of average execution times: Groton Maze Learning Test and Penn Emotion Discrimination Tasks.Notes: In the graphs are given the value of the average rank results, which proved to be significant.

Mentions: The ability to recognize emotions in others, measured by the Reading the Mind in the Eyes Test, is worse in patients after thalamic stroke compared with the control group, thus suggesting their reduced ability to empathize (U=14.50, P=0.06) (Figure 1). In addition, the analysis revealed the presence of a significant difference between the study group and control group in Penn Emotion Discrimination Tasks (EmoDiff40), especially relating to the time taken to recognize the happy emotion: U=13; P=0.02. The time taken to identify happy emotions is significantly longer in patients with thalamic stroke, compared to respondents in the control group (Figure 2).


Social cognitive and neurocognitive deficits in inpatients with unilateral thalamic lesions - pilot study.

Wilkos E, Brown TJ, Slawinska K, Kucharska KA - Neuropsychiatr Dis Treat (2015)

Comparison of average execution times: Groton Maze Learning Test and Penn Emotion Discrimination Tasks.Notes: In the graphs are given the value of the average rank results, which proved to be significant.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401357&req=5

f2-ndt-11-1031: Comparison of average execution times: Groton Maze Learning Test and Penn Emotion Discrimination Tasks.Notes: In the graphs are given the value of the average rank results, which proved to be significant.
Mentions: The ability to recognize emotions in others, measured by the Reading the Mind in the Eyes Test, is worse in patients after thalamic stroke compared with the control group, thus suggesting their reduced ability to empathize (U=14.50, P=0.06) (Figure 1). In addition, the analysis revealed the presence of a significant difference between the study group and control group in Penn Emotion Discrimination Tasks (EmoDiff40), especially relating to the time taken to recognize the happy emotion: U=13; P=0.02. The time taken to identify happy emotions is significantly longer in patients with thalamic stroke, compared to respondents in the control group (Figure 2).

Bottom Line: Furthermore, compared to healthy controls, patients showed significantly delayed recognition of "happiness" in EmoDiff40 and significantly worse performance on Reading the Mind in the Eyes Test, revised version II.Neuropsychological assessment demonstrated some statistically significant deficits in learning and remembering both verbal and visual material, long-term information storing, problem solving, and executive functions such as verbal fluency.Further research is needed to increase understanding about diagnosis, early treatment, and prognosis of patients with thalamic lesions.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroses, Personality and Eating Disorders Institute of Psychiatry and Neurology, Warsaw, Poland.

ABSTRACT

Background: The essential role of the thalamus in neurocognitive processes has been well documented. In contrast, relatively little is known about its involvement in social cognitive processes such as recognition of emotion, mentalizing, or empathy.

The aim of the study: This study was designed to compare the performance of eight patients (five males, three females, mean age ± SD: 63.7±7.9 years) at early stage of unilateral thalamic lesions and eleven healthy controls (six males, five females, 49.6±12.2 years) in neurocognitive tests (CogState Battery: Groton Maze Learning Test, GML; Groton Maze Learning Test-Delayed Recall, GML-DR; Detection Task, DT; Identification Task, IT; One Card Learning Task, OCLT; One Back Task, OBT; Two Back Task, TBT; Set-Shifting Task, S-ST) and other well-known tests (Benton Visual Retention Test, BVRT; California Verbal Learning Test, CVLT; The Rey-Osterrieth Complex Figure Test, ROCF; Trail Making Test, TMT part A and B; Color - Word Stroop Task, CWST; Verbal Fluency Test, VFT), and social cognitive tasks (The Penn Emotion Recognition Test, ER40; Penn Emotion Discrimination Task, EmoDiff40; The Penn Emotional Acuity Test, PEAT40; Reading the Mind in the Eyes Test, revised version II; Toronto Alexithymia Scale, TAS-20).

Methods: Thalamic-damaged subjects were included if they experienced a single-episode ischemic stroke localized in right or left thalamus. The patients were examined at 3 weeks after the stroke onset. All were right handed. In addition, the following clinical scales were used: the Mini-Mental State Examination (MMSE), Spielberger State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI II). An inclusion criteria was a minimum score of 23/30 in MMSE.

Results: Compared with the healthy controls, patients revealed significantly lower scores in CVLT, GML-DR, and VFT. Furthermore, compared to healthy controls, patients showed significantly delayed recognition of "happiness" in EmoDiff40 and significantly worse performance on Reading the Mind in the Eyes Test, revised version II. Neuropsychological assessment demonstrated some statistically significant deficits in learning and remembering both verbal and visual material, long-term information storing, problem solving, and executive functions such as verbal fluency.

Conclusion: Patients at early stage of unilateral thalamic stroke showed both neurocognitive and social cognitive deficits. Further research is needed to increase understanding about diagnosis, early treatment, and prognosis of patients with thalamic lesions.

No MeSH data available.


Related in: MedlinePlus