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Oral submucous fibrosis: an update.

Wollina U, Verma SB, Ali FM, Patil K - Clin Cosmet Investig Dermatol (2015)

Bottom Line: OSF is a diagnosis based on clinical symptoms and confirmation by histopathology.Surgery may be necessary in advanced cases of trismus.Prevention is most important, as no healing can be achieved with available treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.

ABSTRACT
Oral submucous fibrosis (OSF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments.

No MeSH data available.


Related in: MedlinePlus

Dental staining and irregular cobble-stone pattern of oral mucosa.
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f2-ccid-8-193: Dental staining and irregular cobble-stone pattern of oral mucosa.

Mentions: Betel chewing leads to blood-red saliva that stains teeth and gingiva. The teeth may become red-brown to nearly black (Figure 2).1,13 Betel chewer’s mucosa (BCM) is characterized by a brownish-red discoloration and an irregular epithelial surface (Figures 3 and 4). The prevalence of BCM reaches up to 60% with a preference for female sex. The epithelium is often hyperplastic (Figure 4). In contrast to OSF, BCM is not premalignant.50–52


Oral submucous fibrosis: an update.

Wollina U, Verma SB, Ali FM, Patil K - Clin Cosmet Investig Dermatol (2015)

Dental staining and irregular cobble-stone pattern of oral mucosa.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401336&req=5

f2-ccid-8-193: Dental staining and irregular cobble-stone pattern of oral mucosa.
Mentions: Betel chewing leads to blood-red saliva that stains teeth and gingiva. The teeth may become red-brown to nearly black (Figure 2).1,13 Betel chewer’s mucosa (BCM) is characterized by a brownish-red discoloration and an irregular epithelial surface (Figures 3 and 4). The prevalence of BCM reaches up to 60% with a preference for female sex. The epithelium is often hyperplastic (Figure 4). In contrast to OSF, BCM is not premalignant.50–52

Bottom Line: OSF is a diagnosis based on clinical symptoms and confirmation by histopathology.Surgery may be necessary in advanced cases of trismus.Prevention is most important, as no healing can be achieved with available treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.

ABSTRACT
Oral submucous fibrosis (OSF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments.

No MeSH data available.


Related in: MedlinePlus