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Oral submucous fibrosis: an update.

Wollina U, Verma SB, Ali FM, Patil K - Clin Cosmet Investig Dermatol (2015)

Bottom Line: OSF is a diagnosis based on clinical symptoms and confirmation by histopathology.Surgery may be necessary in advanced cases of trismus.Prevention is most important, as no healing can be achieved with available treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.

ABSTRACT
Oral submucous fibrosis (OSF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments.

No MeSH data available.


Related in: MedlinePlus

Histopathological picture showing advanced stage of oral submucous fibrosis.Notes: (A) Hematoxylin and eosin staining, ×100. (B) Closer view (hematoxylin and eosin staining, ×400).
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f10-ccid-8-193: Histopathological picture showing advanced stage of oral submucous fibrosis.Notes: (A) Hematoxylin and eosin staining, ×100. (B) Closer view (hematoxylin and eosin staining, ×400).

Mentions: In more-advanced stages, OSF is characterized by formation of thick bands of collagen and hyalinization extending into the submucosal tissues and decreased vascularity (Figure 10A and B). The epithelium becomes thinner or hyperkeratotic. Inflammation and fibrosis of minor salivary glands may develop. Muscle degeneration will occur in advanced stages of OSF.1,82,89 In vivo autofluorescence from buccal mucosa seems to be an interesting noninvasive tool to differentiate normal mucosa from OSF and early carcinoma.82


Oral submucous fibrosis: an update.

Wollina U, Verma SB, Ali FM, Patil K - Clin Cosmet Investig Dermatol (2015)

Histopathological picture showing advanced stage of oral submucous fibrosis.Notes: (A) Hematoxylin and eosin staining, ×100. (B) Closer view (hematoxylin and eosin staining, ×400).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401336&req=5

f10-ccid-8-193: Histopathological picture showing advanced stage of oral submucous fibrosis.Notes: (A) Hematoxylin and eosin staining, ×100. (B) Closer view (hematoxylin and eosin staining, ×400).
Mentions: In more-advanced stages, OSF is characterized by formation of thick bands of collagen and hyalinization extending into the submucosal tissues and decreased vascularity (Figure 10A and B). The epithelium becomes thinner or hyperkeratotic. Inflammation and fibrosis of minor salivary glands may develop. Muscle degeneration will occur in advanced stages of OSF.1,82,89 In vivo autofluorescence from buccal mucosa seems to be an interesting noninvasive tool to differentiate normal mucosa from OSF and early carcinoma.82

Bottom Line: OSF is a diagnosis based on clinical symptoms and confirmation by histopathology.Surgery may be necessary in advanced cases of trismus.Prevention is most important, as no healing can be achieved with available treatments.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.

ABSTRACT
Oral submucous fibrosis (OSF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments.

No MeSH data available.


Related in: MedlinePlus