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Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients.

Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M, Hokkaido COPD Cohort Study Investigato - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners.Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ.The longitudinal changes of quality of life and their determinants are markedly different and independent between its components.

View Article: PubMed Central - PubMed

Affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

ABSTRACT

Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD).

Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on AFEV1/year.

Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement.

Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

No MeSH data available.


Related in: MedlinePlus

The relationship between the annual change in postbronchodilator FeV1.Note: The annual change in SGRQ total score is negatively correlated with the annual change in FEV1 (r=−0.27, P<0.001, n=261).Abbreviations: FEV1, forced expiratory volume in 1 second; SGRQ, St George’s Respiratory Questionnaire.
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f2-copd-10-745: The relationship between the annual change in postbronchodilator FeV1.Note: The annual change in SGRQ total score is negatively correlated with the annual change in FEV1 (r=−0.27, P<0.001, n=261).Abbreviations: FEV1, forced expiratory volume in 1 second; SGRQ, St George’s Respiratory Questionnaire.

Mentions: The association between pulmonary function decline and the annual change in SGRQ was also analyzed. At baseline, there were no significant differences in spirometric data, smoking status (Table S2), and the total score or each component score of the SGRQ (Table S3) among the three groups classified by annualized ΔFEV1, as described previously. During the follow-up period, smoking status, exacerbation frequency, and medication did not differ among the three groups.6 A brief extract of study protocol taken from the original manuscript is shown in supplementary material. Annual change in SGRQ total score was weakly but significantly correlated with the annualized ΔFEV1 (mL/year) (r=−0.27, P<0.001, n=261) despite the absence of differences in SGRQ total score at baseline among the three groups classified by annualized ΔFEV (Figure 2). It is noteworthy that 110 subjects (42%) improved their SGRQ total score, even if the annualized ΔFEV1 decreased over 5 years (lower left square marked with dotted lines in Figure 2).


Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients.

Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M, Hokkaido COPD Cohort Study Investigato - Int J Chron Obstruct Pulmon Dis (2015)

The relationship between the annual change in postbronchodilator FeV1.Note: The annual change in SGRQ total score is negatively correlated with the annual change in FEV1 (r=−0.27, P<0.001, n=261).Abbreviations: FEV1, forced expiratory volume in 1 second; SGRQ, St George’s Respiratory Questionnaire.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401330&req=5

f2-copd-10-745: The relationship between the annual change in postbronchodilator FeV1.Note: The annual change in SGRQ total score is negatively correlated with the annual change in FEV1 (r=−0.27, P<0.001, n=261).Abbreviations: FEV1, forced expiratory volume in 1 second; SGRQ, St George’s Respiratory Questionnaire.
Mentions: The association between pulmonary function decline and the annual change in SGRQ was also analyzed. At baseline, there were no significant differences in spirometric data, smoking status (Table S2), and the total score or each component score of the SGRQ (Table S3) among the three groups classified by annualized ΔFEV1, as described previously. During the follow-up period, smoking status, exacerbation frequency, and medication did not differ among the three groups.6 A brief extract of study protocol taken from the original manuscript is shown in supplementary material. Annual change in SGRQ total score was weakly but significantly correlated with the annualized ΔFEV1 (mL/year) (r=−0.27, P<0.001, n=261) despite the absence of differences in SGRQ total score at baseline among the three groups classified by annualized ΔFEV (Figure 2). It is noteworthy that 110 subjects (42%) improved their SGRQ total score, even if the annualized ΔFEV1 decreased over 5 years (lower left square marked with dotted lines in Figure 2).

Bottom Line: In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners.Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ.The longitudinal changes of quality of life and their determinants are markedly different and independent between its components.

View Article: PubMed Central - PubMed

Affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

ABSTRACT

Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD).

Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on AFEV1/year.

Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement.

Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

No MeSH data available.


Related in: MedlinePlus