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Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients.

Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M, Hokkaido COPD Cohort Study Investigato - Int J Chron Obstruct Pulmon Dis (2015)

Bottom Line: In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners.Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ.The longitudinal changes of quality of life and their determinants are markedly different and independent between its components.

View Article: PubMed Central - PubMed

Affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

ABSTRACT

Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD).

Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on AFEV1/year.

Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement.

Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

No MeSH data available.


Related in: MedlinePlus

The frequency distributions of the annual change in SGRQ (units/year).Notes: The calculated annual change in the SGRQ activity score is 1.22±3.53 (mean ± SD) (A), symptom score is −1.96±4.22 (B).Abbreviation: SGRQ, St George’s Respiratory Questionnaire; SD, standard deviation.
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f1-copd-10-745: The frequency distributions of the annual change in SGRQ (units/year).Notes: The calculated annual change in the SGRQ activity score is 1.22±3.53 (mean ± SD) (A), symptom score is −1.96±4.22 (B).Abbreviation: SGRQ, St George’s Respiratory Questionnaire; SD, standard deviation.

Mentions: The calculated annual change in the SGRQ total score (units/year) was 0.06±2.64 (Figure S1). The frequency distributions of the annual changes in SGRQ activity and symptom component scores are shown in Figure 1A and B, which illustrate how these two component scores change differently over time. There were subjects with improvement (negative number) and deterioration (positive number) of annual change in SGRQ scores. In other words, it revealed that a large number of subjects showed improvement in their symptom score under appropriate treatment, even though many subjects showed deterioration in their activity score.


Differential changes in quality of life components over 5 years in chronic obstructive pulmonary disease patients.

Nagai K, Makita H, Suzuki M, Shimizu K, Konno S, Ito YM, Nishimura M, Hokkaido COPD Cohort Study Investigato - Int J Chron Obstruct Pulmon Dis (2015)

The frequency distributions of the annual change in SGRQ (units/year).Notes: The calculated annual change in the SGRQ activity score is 1.22±3.53 (mean ± SD) (A), symptom score is −1.96±4.22 (B).Abbreviation: SGRQ, St George’s Respiratory Questionnaire; SD, standard deviation.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401330&req=5

f1-copd-10-745: The frequency distributions of the annual change in SGRQ (units/year).Notes: The calculated annual change in the SGRQ activity score is 1.22±3.53 (mean ± SD) (A), symptom score is −1.96±4.22 (B).Abbreviation: SGRQ, St George’s Respiratory Questionnaire; SD, standard deviation.
Mentions: The calculated annual change in the SGRQ total score (units/year) was 0.06±2.64 (Figure S1). The frequency distributions of the annual changes in SGRQ activity and symptom component scores are shown in Figure 1A and B, which illustrate how these two component scores change differently over time. There were subjects with improvement (negative number) and deterioration (positive number) of annual change in SGRQ scores. In other words, it revealed that a large number of subjects showed improvement in their symptom score under appropriate treatment, even though many subjects showed deterioration in their activity score.

Bottom Line: In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners.Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ.The longitudinal changes of quality of life and their determinants are markedly different and independent between its components.

View Article: PubMed Central - PubMed

Affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

ABSTRACT

Background: The aim of the study was to examine the longitudinal change in quality of life components of patients with chronic obstructive pulmonary disease (COPD).

Methods: In the Hokkaido COPD Cohort Study, 261 subjects were appropriately treated and followed over 5 years with a 74% follow-up rate at the end. The longitudinal changes in St George's Respiratory Questionnaire (SGRQ) scores were annually evaluated with forced expiratory volume in 1 second (FEV1). The subjects were classified into the rapid decliners, slow decliners, and sustainers based on AFEV1/year.

Results: The activity component of SGRQ generally deteriorated over time, and its annual decline was the greatest in the rapid decliners (<25th percentile). In contrast, the symptom component improved significantly year by year in the sustainers (>75 percentile), and it did not deteriorate even in the rapid decliners. Of the baseline data, predictors for worsening of the activity component were older age and lower body mass index. Larger reversibility was related to symptom component improvement. Of the follow-up data, AFEV1/year was the best predictor for worsening of the components of SGRQ. Continuous smoking was another factor for worsening of the activity component. For the symptom component, a history of exacerbation by admission definition was the determinant of its deterioration, whereas use of beta agonists was related to improvement.

Conclusion: The longitudinal changes of quality of life and their determinants are markedly different and independent between its components. The activity component of SGRQ generally deteriorated over years, while the symptom component rather improved in some patients with COPD under appropriate treatment.

No MeSH data available.


Related in: MedlinePlus