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Laboratory diagnostics of chronic kidney disease in Croatia: state of the art.

Biljak VR, Honović L, Matica J, Knežević B, Vojak SŠ - Biochem Med (Zagreb) (2015)

Bottom Line: Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease.The questionnaire was designed in a form of questions and statements, with possible multiple answers, comprising 24 questions.The two key prerequisites for CKD screening, automatic reporting of eGFR and albuminuria or proteinuria assessment, are not implemented nationwide.

View Article: PubMed Central - PubMed

Affiliation: Department of medical biochemistry and laboratory medicine, Merkur University Hospital, Zagreb, Croatia.

ABSTRACT

Introduction: Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical biochemistry and laboratory medicine (CSMBLM) and Croatian chamber of medical biochemists (CCMB) conducted a survey across Croatian medical-biochemistry laboratories to assess the current practice in this area of laboratory medicine. The aim of this study was to present the data collected through the survey and to give insight about laboratory diagnostics of chronic kidney disease in Croatia.

Materials and methods: An invitation to participate in the survey was sent to all Croatian medical-biochemistry laboratories (N=196). The questionnaire was designed in a form of questions and statements, with possible multiple answers, comprising 24 questions.

Results: The response rate was 80/196 (40.8%). 39 answers were from primary medical-biochemistry laboratories. 31/78 (0.40) laboratories measure creatinine with non-standardized method (uncompensated Jaffe method). 58/78 (0.74) of laboratories that measure creatinine do not report eGFR values. Similar number of laboratories (58/80, 0.73) do not measure urine albumin or protein.

Conclusions: There is a large heterogeneity among Croatian laboratories regarding measuring methods, reporting units and reference intervals (cut-off values), both for creatinine and urine albumin or protein. The two key prerequisites for CKD screening, automatic reporting of eGFR and albuminuria or proteinuria assessment, are not implemented nationwide. There is a need for harmonization in laboratory diagnostics of CKD in Croatia.

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Related in: MedlinePlus

Comparison of number of laboratories that report eGFR values by type of institution in Croatia, N = 78.
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getmorefigures.php?uid=PMC4401307&req=5

f1: Comparison of number of laboratories that report eGFR values by type of institution in Croatia, N = 78.

Mentions: The majority of laboratories generally do not report results for eGFR (58/78). There was a statistically significant difference in distribution of laboratories that report eGFR by type of institution (P < 0.001), with the lowest number of laboratories from primary health care institutions (Figure 1.).


Laboratory diagnostics of chronic kidney disease in Croatia: state of the art.

Biljak VR, Honović L, Matica J, Knežević B, Vojak SŠ - Biochem Med (Zagreb) (2015)

Comparison of number of laboratories that report eGFR values by type of institution in Croatia, N = 78.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401307&req=5

f1: Comparison of number of laboratories that report eGFR values by type of institution in Croatia, N = 78.
Mentions: The majority of laboratories generally do not report results for eGFR (58/78). There was a statistically significant difference in distribution of laboratories that report eGFR by type of institution (P < 0.001), with the lowest number of laboratories from primary health care institutions (Figure 1.).

Bottom Line: Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease.The questionnaire was designed in a form of questions and statements, with possible multiple answers, comprising 24 questions.The two key prerequisites for CKD screening, automatic reporting of eGFR and albuminuria or proteinuria assessment, are not implemented nationwide.

View Article: PubMed Central - PubMed

Affiliation: Department of medical biochemistry and laboratory medicine, Merkur University Hospital, Zagreb, Croatia.

ABSTRACT

Introduction: Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical biochemistry and laboratory medicine (CSMBLM) and Croatian chamber of medical biochemists (CCMB) conducted a survey across Croatian medical-biochemistry laboratories to assess the current practice in this area of laboratory medicine. The aim of this study was to present the data collected through the survey and to give insight about laboratory diagnostics of chronic kidney disease in Croatia.

Materials and methods: An invitation to participate in the survey was sent to all Croatian medical-biochemistry laboratories (N=196). The questionnaire was designed in a form of questions and statements, with possible multiple answers, comprising 24 questions.

Results: The response rate was 80/196 (40.8%). 39 answers were from primary medical-biochemistry laboratories. 31/78 (0.40) laboratories measure creatinine with non-standardized method (uncompensated Jaffe method). 58/78 (0.74) of laboratories that measure creatinine do not report eGFR values. Similar number of laboratories (58/80, 0.73) do not measure urine albumin or protein.

Conclusions: There is a large heterogeneity among Croatian laboratories regarding measuring methods, reporting units and reference intervals (cut-off values), both for creatinine and urine albumin or protein. The two key prerequisites for CKD screening, automatic reporting of eGFR and albuminuria or proteinuria assessment, are not implemented nationwide. There is a need for harmonization in laboratory diagnostics of CKD in Croatia.

Show MeSH
Related in: MedlinePlus