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Calcium-associated mechanisms in gut pacemaker activity.

Nakayama S, Kajioka S, Goto K, Takaki M, Liu HN - J. Cell. Mol. Med. (2007 Sep-Oct)

Bottom Line: A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca(2+) activity in ICC as the probable primary mechanism.Namely, intracellular (cytosolic) Ca(2+) oscillations in ICC periodically activate plasmalemmal Ca(2+)-dependent ion channels and thereby generate pacemaker potentials.This review will, thus, focus on Ca(2+)-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. h44673a@nucc.cc.nagoya-u.ac.jp

ABSTRACT
A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca(2+) activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca(2+) oscillations in ICC periodically activate plasmalemmal Ca(2+)-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca(2+)-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Show MeSH
Plausible mechanisms linking spontaneous [Ca2+]i oscillations and pacemaker potentials in ICC.
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fig03: Plausible mechanisms linking spontaneous [Ca2+]i oscillations and pacemaker potentials in ICC.

Mentions: Using cell cluster preparations from the murine small intestine, Torihashi et al.[27] and Nakayama et al.[23] recorded [Ca2+]i oscillations synchronized with spontaneous electrical and mechanical activities (Fig. 2). These results agree well with the hypothesis that [Ca2+]i oscillations in ICC generate pacemaker electrical activity by periodically activating Ca2+-activated ion channels in the plasma membrane (Scenario 1 in Fig. 3). Moreover, in guinea-pig and mouse stomach ICC, [Ca2+]i oscillations appear to be associated with spontaneous electrical and mechanical activities [26,54–56].


Calcium-associated mechanisms in gut pacemaker activity.

Nakayama S, Kajioka S, Goto K, Takaki M, Liu HN - J. Cell. Mol. Med. (2007 Sep-Oct)

Plausible mechanisms linking spontaneous [Ca2+]i oscillations and pacemaker potentials in ICC.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401267&req=5

fig03: Plausible mechanisms linking spontaneous [Ca2+]i oscillations and pacemaker potentials in ICC.
Mentions: Using cell cluster preparations from the murine small intestine, Torihashi et al.[27] and Nakayama et al.[23] recorded [Ca2+]i oscillations synchronized with spontaneous electrical and mechanical activities (Fig. 2). These results agree well with the hypothesis that [Ca2+]i oscillations in ICC generate pacemaker electrical activity by periodically activating Ca2+-activated ion channels in the plasma membrane (Scenario 1 in Fig. 3). Moreover, in guinea-pig and mouse stomach ICC, [Ca2+]i oscillations appear to be associated with spontaneous electrical and mechanical activities [26,54–56].

Bottom Line: A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca(2+) activity in ICC as the probable primary mechanism.Namely, intracellular (cytosolic) Ca(2+) oscillations in ICC periodically activate plasmalemmal Ca(2+)-dependent ion channels and thereby generate pacemaker potentials.This review will, thus, focus on Ca(2+)-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. h44673a@nucc.cc.nagoya-u.ac.jp

ABSTRACT
A considerable body of evidence has revealed that interstitial cells of Cajal (ICC), identified with c-Kit-immunoreactivity, act as gut pacemaker cells, with spontaneous Ca(2+) activity in ICC as the probable primary mechanism. Namely, intracellular (cytosolic) Ca(2+) oscillations in ICC periodically activate plasmalemmal Ca(2+)-dependent ion channels and thereby generate pacemaker potentials. This review will, thus, focus on Ca(2+)-associated mechanisms in ICC in the gastrointestinal (GI) tract, including auxiliary organs.

Show MeSH