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Stem cell differentiation and expansion for clinical applications of tissue engineering.

Guillot PV, Cui W, Fisk NM, Polak DJ - J. Cell. Mol. Med. (2007 Sep-Oct)

Bottom Line: This invited review discusses the latest advances stem cell biology, tissue engineering and the transition from bench to bedside.An overview is presented as to which the best cell source might be for cell therapy and tissue engineering applications, best biomaterials currently available and the challenges the field faces to translate basic research into therapies for a large number of human diseases.

View Article: PubMed Central - PubMed

Affiliation: Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, London, UK.

ABSTRACT
This invited review discusses the latest advances stem cell biology, tissue engineering and the transition from bench to bedside. An overview is presented as to which the best cell source might be for cell therapy and tissue engineering applications, best biomaterials currently available and the challenges the field faces to translate basic research into therapies for a large number of human diseases.

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Related in: MedlinePlus

Human first trimester foetal mesenchymal stem cell present a fibroblastic spindle-like morphology visualized by crystal violet staining (A), are readily expandable (B) and express oct-4 (C), nanog (D) and hTERT both in the nucleus (active fraction) and in the cytoplasm (trafficking fraction) (E).
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fig02: Human first trimester foetal mesenchymal stem cell present a fibroblastic spindle-like morphology visualized by crystal violet staining (A), are readily expandable (B) and express oct-4 (C), nanog (D) and hTERT both in the nucleus (active fraction) and in the cytoplasm (trafficking fraction) (E).

Mentions: Foetal MSC are less lineage committed than adult MSC in humans [31–33] and primates. [34]. Human first trimester foetal MSC found in blood, liver, bone marrow, amniotic fluid and trophoblast are more primitive that adult bone marrow MSC, expressing markers associated with pluripotency and having high levels of telomerase activity (Fig. 2) [35].


Stem cell differentiation and expansion for clinical applications of tissue engineering.

Guillot PV, Cui W, Fisk NM, Polak DJ - J. Cell. Mol. Med. (2007 Sep-Oct)

Human first trimester foetal mesenchymal stem cell present a fibroblastic spindle-like morphology visualized by crystal violet staining (A), are readily expandable (B) and express oct-4 (C), nanog (D) and hTERT both in the nucleus (active fraction) and in the cytoplasm (trafficking fraction) (E).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401265&req=5

fig02: Human first trimester foetal mesenchymal stem cell present a fibroblastic spindle-like morphology visualized by crystal violet staining (A), are readily expandable (B) and express oct-4 (C), nanog (D) and hTERT both in the nucleus (active fraction) and in the cytoplasm (trafficking fraction) (E).
Mentions: Foetal MSC are less lineage committed than adult MSC in humans [31–33] and primates. [34]. Human first trimester foetal MSC found in blood, liver, bone marrow, amniotic fluid and trophoblast are more primitive that adult bone marrow MSC, expressing markers associated with pluripotency and having high levels of telomerase activity (Fig. 2) [35].

Bottom Line: This invited review discusses the latest advances stem cell biology, tissue engineering and the transition from bench to bedside.An overview is presented as to which the best cell source might be for cell therapy and tissue engineering applications, best biomaterials currently available and the challenges the field faces to translate basic research into therapies for a large number of human diseases.

View Article: PubMed Central - PubMed

Affiliation: Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Hospital Campus, London, UK.

ABSTRACT
This invited review discusses the latest advances stem cell biology, tissue engineering and the transition from bench to bedside. An overview is presented as to which the best cell source might be for cell therapy and tissue engineering applications, best biomaterials currently available and the challenges the field faces to translate basic research into therapies for a large number of human diseases.

Show MeSH
Related in: MedlinePlus