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Copeptin: a new predictor for severe obstructive sleep apnea.

Çınarka H, Kayhan S, Karataş M, Yavuz A, Gümüş A, Özyurt S, Cüre MC, Şahin Ü - Ther Clin Risk Manag (2015)

Bottom Line: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis.Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001).Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Chest Diseases, Recep Tayyip Erdogğan University, Rize, Turkey.

ABSTRACT

Introduction: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis. Patients with obstructive sleep apnea syndrome (OSAS) have a tendency to develop coronary and cerebral atherosclerotic diseases.

Objectives: The aim of the present study was to study copeptin levels in patients with obstructive sleep apnea and in a control group in order to determine whether copeptin could be used as a biomarker predicting the severity of OSAS and possible complications in this group.

Methods: A total of 116 patients with OSAS, diagnosed by polysomnography, and 27 controls were included in the study. Blood samples were collected after overnight fasting, and copeptin levels were measured with enzyme-linked immunosorbent assay.

Results: Copeptin levels were significantly higher in the OSAS group compared to control group (2,156±502; 1,845±500 pg/mL, respectively, P=0.004). Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001). A multivariate regression analysis showed that copeptin level, (hazard ratio: 1.58; 95% confidence interval: 1.09-2.30) was a predictor of severe OSAS (P=0.016). Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively.

Conclusion: Copeptin levels are high in OSAS patients and copeptin is a potential marker for identifying patients with a high risk of early cardiovascular complications of OSAS. Copeptin has modest sensitivity (84%) for discriminating severe OSAS patients who are candidates for severe cardiovascular complications.

No MeSH data available.


Related in: MedlinePlus

Correlation analysis by Spearman test between copeptin levels and desaturation index (r=0.23; P=0.012).
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f5-tcrm-11-589: Correlation analysis by Spearman test between copeptin levels and desaturation index (r=0.23; P=0.012).

Mentions: In univariate analysis, a significant association was found between severe OSAS and age, body mass index, copeptin level, and C-reactive protein (CRP) level. CRP and copeptin levels were analyzed from the same blood samples of the study population. A multivariate regression analysis showed that the copeptin level (hazard ratio 1.58, 95% CI 1.09–2.30) was a predictor of severe OSAS (P=0.016). Other potential predictors for severe OSAS on multivariate regression analysis are summarized in Table 2. Copeptin levels showed a significant positive correlation with AHI (r=0.32; P<0.001, Figure 4), desaturation index (r=0.23; P=0.012, Figure 5), arousal index (r=0.24; P=0.010, Figure 6), and CRP level (r=0.26; P=0.011, Figure 7).


Copeptin: a new predictor for severe obstructive sleep apnea.

Çınarka H, Kayhan S, Karataş M, Yavuz A, Gümüş A, Özyurt S, Cüre MC, Şahin Ü - Ther Clin Risk Manag (2015)

Correlation analysis by Spearman test between copeptin levels and desaturation index (r=0.23; P=0.012).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401209&req=5

f5-tcrm-11-589: Correlation analysis by Spearman test between copeptin levels and desaturation index (r=0.23; P=0.012).
Mentions: In univariate analysis, a significant association was found between severe OSAS and age, body mass index, copeptin level, and C-reactive protein (CRP) level. CRP and copeptin levels were analyzed from the same blood samples of the study population. A multivariate regression analysis showed that the copeptin level (hazard ratio 1.58, 95% CI 1.09–2.30) was a predictor of severe OSAS (P=0.016). Other potential predictors for severe OSAS on multivariate regression analysis are summarized in Table 2. Copeptin levels showed a significant positive correlation with AHI (r=0.32; P<0.001, Figure 4), desaturation index (r=0.23; P=0.012, Figure 5), arousal index (r=0.24; P=0.010, Figure 6), and CRP level (r=0.26; P=0.011, Figure 7).

Bottom Line: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis.Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001).Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Chest Diseases, Recep Tayyip Erdogğan University, Rize, Turkey.

ABSTRACT

Introduction: Copeptin which is the C-terminal fragment of antidiuretic hormone (ADH), is a biomarker that has been reported to be increased in various cardiovascular disorders, cerebrovascular diseases and associated with prognosis. Patients with obstructive sleep apnea syndrome (OSAS) have a tendency to develop coronary and cerebral atherosclerotic diseases.

Objectives: The aim of the present study was to study copeptin levels in patients with obstructive sleep apnea and in a control group in order to determine whether copeptin could be used as a biomarker predicting the severity of OSAS and possible complications in this group.

Methods: A total of 116 patients with OSAS, diagnosed by polysomnography, and 27 controls were included in the study. Blood samples were collected after overnight fasting, and copeptin levels were measured with enzyme-linked immunosorbent assay.

Results: Copeptin levels were significantly higher in the OSAS group compared to control group (2,156±502; 1,845±500 pg/mL, respectively, P=0.004). Mean copeptin level of the patients having apnea-hypopnea index (AHI) ≥30 was significantly higher than that of the patients having AHI <30 (2,392±415; 2,017±500 pg/mL, respectively, P<0.001). A multivariate regression analysis showed that copeptin level, (hazard ratio: 1.58; 95% confidence interval: 1.09-2.30) was a predictor of severe OSAS (P=0.016). Copeptin levels showed significant positive correlation with AHI (r=0.32; P<0.001), desaturation index (r=0.23; P=0.012), arousal index (r=0.24; P=0.010) and CRP (r=0.26; P=0.011) respectively.

Conclusion: Copeptin levels are high in OSAS patients and copeptin is a potential marker for identifying patients with a high risk of early cardiovascular complications of OSAS. Copeptin has modest sensitivity (84%) for discriminating severe OSAS patients who are candidates for severe cardiovascular complications.

No MeSH data available.


Related in: MedlinePlus