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Alogliptin benzoate for management of type 2 diabetes.

Saisho Y - Vasc Health Risk Manag (2015)

Bottom Line: DPP-4 inhibitors are generally well tolerated because of their low risk of hypoglycemia and other adverse events.Alogliptin benzoate is a newly developed, highly selective DPP-4 inhibitor which has been approved in many countries throughout the world.Once-daily administration of alogliptin as either monotherapy or combination therapy with other oral antidiabetic drugs or insulin has a potent glucose-lowering effect which is similar to that of other DPP-4 inhibitors, with a low risk of hypoglycemia and weight gain.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

ABSTRACT
Dipeptidyl peptidase-4 (DPP-4) inhibitors, a new class of oral hypoglycemic agents, augment glucose-dependent insulin secretion and suppress glucagon levels through enhancement of the action of endogenous incretin by inhibiting DPP-4, an incretin-degrading enzyme. DPP-4 inhibitors are generally well tolerated because of their low risk of hypoglycemia and other adverse events. Moreover, with their potential to improve beta cell function, a core defect of type 2 diabetes, DPP-4 inhibitors are becoming a major component of treatment of type 2 diabetes. Alogliptin benzoate is a newly developed, highly selective DPP-4 inhibitor which has been approved in many countries throughout the world. Once-daily administration of alogliptin as either monotherapy or combination therapy with other oral antidiabetic drugs or insulin has a potent glucose-lowering effect which is similar to that of other DPP-4 inhibitors, with a low risk of hypoglycemia and weight gain. The cardiovascular safety of this drug has been confirmed in a recent randomized controlled trial. This review summarizes the efficacy and safety of alogliptin, and discusses the role of DPP-4 inhibitors in the treatment of type 2 diabetes.

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Related in: MedlinePlus

Chemical structure of alogliptin benzoate: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl) benzonitrile monobenzoate.
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f1-vhrm-11-229: Chemical structure of alogliptin benzoate: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl) benzonitrile monobenzoate.

Mentions: The chemical structure of alogliptin is shown in Figure 1. Alogliptin shows high selectivity for DPP-4 (>10,000-fold over other DPP isozymes such as DPP-2, DPP-8, and DPP-9.2,7 High selectivity of alogliptin for DPP-4 has also been confirmed in a DPP-8/9-expressing cell model.8 A recent study using X-ray crystallography revealed that alogliptin interacts with the S1 and/or S2 subsites in addition to the S1 and S2 subsites of DPP-4, where vildagliptin interacts, suggesting that alogliptin offers more potent DPP-4 inhibition compared with vildagliptin.9


Alogliptin benzoate for management of type 2 diabetes.

Saisho Y - Vasc Health Risk Manag (2015)

Chemical structure of alogliptin benzoate: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl) benzonitrile monobenzoate.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401208&req=5

f1-vhrm-11-229: Chemical structure of alogliptin benzoate: 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl) benzonitrile monobenzoate.
Mentions: The chemical structure of alogliptin is shown in Figure 1. Alogliptin shows high selectivity for DPP-4 (>10,000-fold over other DPP isozymes such as DPP-2, DPP-8, and DPP-9.2,7 High selectivity of alogliptin for DPP-4 has also been confirmed in a DPP-8/9-expressing cell model.8 A recent study using X-ray crystallography revealed that alogliptin interacts with the S1 and/or S2 subsites in addition to the S1 and S2 subsites of DPP-4, where vildagliptin interacts, suggesting that alogliptin offers more potent DPP-4 inhibition compared with vildagliptin.9

Bottom Line: DPP-4 inhibitors are generally well tolerated because of their low risk of hypoglycemia and other adverse events.Alogliptin benzoate is a newly developed, highly selective DPP-4 inhibitor which has been approved in many countries throughout the world.Once-daily administration of alogliptin as either monotherapy or combination therapy with other oral antidiabetic drugs or insulin has a potent glucose-lowering effect which is similar to that of other DPP-4 inhibitors, with a low risk of hypoglycemia and weight gain.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

ABSTRACT
Dipeptidyl peptidase-4 (DPP-4) inhibitors, a new class of oral hypoglycemic agents, augment glucose-dependent insulin secretion and suppress glucagon levels through enhancement of the action of endogenous incretin by inhibiting DPP-4, an incretin-degrading enzyme. DPP-4 inhibitors are generally well tolerated because of their low risk of hypoglycemia and other adverse events. Moreover, with their potential to improve beta cell function, a core defect of type 2 diabetes, DPP-4 inhibitors are becoming a major component of treatment of type 2 diabetes. Alogliptin benzoate is a newly developed, highly selective DPP-4 inhibitor which has been approved in many countries throughout the world. Once-daily administration of alogliptin as either monotherapy or combination therapy with other oral antidiabetic drugs or insulin has a potent glucose-lowering effect which is similar to that of other DPP-4 inhibitors, with a low risk of hypoglycemia and weight gain. The cardiovascular safety of this drug has been confirmed in a recent randomized controlled trial. This review summarizes the efficacy and safety of alogliptin, and discusses the role of DPP-4 inhibitors in the treatment of type 2 diabetes.

Show MeSH
Related in: MedlinePlus