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Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis.

Yang X, Huang Y, Feng JF, Liu JS - Onco Targets Ther (2015)

Bottom Line: Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32-1.80, I2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25-2.43, I2=63.9%, P=0.096).High NLR is associated with poor prognosis in patients with EC.NLR may be a significant predictive biomarker in patients with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.

ABSTRACT

Background: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC.

Methods: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS).

Results: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32-1.80, I2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25-2.43, I2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS.

Conclusion: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC.

No MeSH data available.


Related in: MedlinePlus

Forest plot of the association between serum CRP and OS in EC by subgroup analyses.Notes: Subgroup analysis by sample size (A: >300, B: ≤300), country (C: People’s Republic of China, D: not People’s Republic of China), and pathological type (E: SCC, F: SCC + AC).Abbreviations: HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; OS, overall survival; EC, esophageal cancer; SCC, squamous cell carcinoma; AC, adenocarcinoma.
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f3-ott-8-789: Forest plot of the association between serum CRP and OS in EC by subgroup analyses.Notes: Subgroup analysis by sample size (A: >300, B: ≤300), country (C: People’s Republic of China, D: not People’s Republic of China), and pathological type (E: SCC, F: SCC + AC).Abbreviations: HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; OS, overall survival; EC, esophageal cancer; SCC, squamous cell carcinoma; AC, adenocarcinoma.

Mentions: In a further investigation, subgroup analyses were performed (Figure 3). When stratified by “sample size,” the “>300” group yielded a HR of 1.41, and the 95% CI was 1.15–1.73 (Figure 3A). The “≤300” group yielded a HR of 1.76, and the 95% CI was 1.38–2.26 (Figure 3B). In the subgroup analysis by “country,” we found that no matter the patients were Chinese (Figure 3C) or non-Chinese (Figure 3D), high NLR was still a poor predictor for OS. The subgroup analysis by “pathological type” showed that high NLR still yielded a worse OS (Figure 3E and F).


Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis.

Yang X, Huang Y, Feng JF, Liu JS - Onco Targets Ther (2015)

Forest plot of the association between serum CRP and OS in EC by subgroup analyses.Notes: Subgroup analysis by sample size (A: >300, B: ≤300), country (C: People’s Republic of China, D: not People’s Republic of China), and pathological type (E: SCC, F: SCC + AC).Abbreviations: HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; OS, overall survival; EC, esophageal cancer; SCC, squamous cell carcinoma; AC, adenocarcinoma.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4401207&req=5

f3-ott-8-789: Forest plot of the association between serum CRP and OS in EC by subgroup analyses.Notes: Subgroup analysis by sample size (A: >300, B: ≤300), country (C: People’s Republic of China, D: not People’s Republic of China), and pathological type (E: SCC, F: SCC + AC).Abbreviations: HR, hazard ratio; CI, confidence interval; CRP, C-reactive protein; OS, overall survival; EC, esophageal cancer; SCC, squamous cell carcinoma; AC, adenocarcinoma.
Mentions: In a further investigation, subgroup analyses were performed (Figure 3). When stratified by “sample size,” the “>300” group yielded a HR of 1.41, and the 95% CI was 1.15–1.73 (Figure 3A). The “≤300” group yielded a HR of 1.76, and the 95% CI was 1.38–2.26 (Figure 3B). In the subgroup analysis by “country,” we found that no matter the patients were Chinese (Figure 3C) or non-Chinese (Figure 3D), high NLR was still a poor predictor for OS. The subgroup analysis by “pathological type” showed that high NLR still yielded a worse OS (Figure 3E and F).

Bottom Line: Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32-1.80, I2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25-2.43, I2=63.9%, P=0.096).High NLR is associated with poor prognosis in patients with EC.NLR may be a significant predictive biomarker in patients with EC.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.

ABSTRACT

Background: The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR in patients with esophageal cancer (EC) is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the prognostic value of NLR in patients with EC.

Methods: A systematic literature search was performed by using Web of Science, PubMed Central, and Medline to evaluate the prognostic value of NLR in patients with EC. The deadline of our primary search was July 10, 2014. This meta-analysis was conducted in accordance with PRISMA guidelines. Pooled hazard ratio (HR) with 95% confidence interval (CI) was used to assess the association of NLR and overall survival (OS) and disease-free survival (DFS).

Results: Six studies involving 1,633 patients were included in our meta-analysis. Our pooled results demonstrated that high NLR was associated with poor OS (HR: 1.54, 95% CI: 1.32-1.80, I2=25.3%, P=0.254) and DFS (HR: 1.74, 95% CI: 1.25-2.43, I2=63.9%, P=0.096). Subgroup analysis between NLR and OS was performed in a further investigation. When the patients were segregated according to country, sample size, and pathological type, high NLR was also significantly correlated with OS.

Conclusion: High NLR is associated with poor prognosis in patients with EC. NLR may be a significant predictive biomarker in patients with EC.

No MeSH data available.


Related in: MedlinePlus