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Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Gastric mucus glycoproteins form an adherent gel of 100-200 μm thick between the tissue and the bulk lumen tissue. Furthermore, the mucus cells secrete a hydrophobic surfactant-like phospholipid monolayer that adsorbs directly onto the mucus gel layer. Contact angle studies of this layer directly correlate with the barrier property of the gastrointestinal tissue (shown in Fig. 4). This membrane is able to stretch and cover the gastrointestinal tract during digestion. These hydrophobic forces increase the surface tension at the aqueous-lipid interface and help to pull the lipid molecules together, hence the membrane can stretch during digestion and prevent deformation. This weak barrier is disrupted when the luminal pH is lower than 2. Amphiphilic molecules such as non steroidal anti inflammatory drugs (NSAIDs) interact and thereby change membrane surface tension. This influences the bending rigidity of the membrane, changes its hydrophobicity fluidity and decreases the mucosal barrier property of the membrane.83


Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401165&req=5

Mentions: Gastric mucus glycoproteins form an adherent gel of 100-200 μm thick between the tissue and the bulk lumen tissue. Furthermore, the mucus cells secrete a hydrophobic surfactant-like phospholipid monolayer that adsorbs directly onto the mucus gel layer. Contact angle studies of this layer directly correlate with the barrier property of the gastrointestinal tissue (shown in Fig. 4). This membrane is able to stretch and cover the gastrointestinal tract during digestion. These hydrophobic forces increase the surface tension at the aqueous-lipid interface and help to pull the lipid molecules together, hence the membrane can stretch during digestion and prevent deformation. This weak barrier is disrupted when the luminal pH is lower than 2. Amphiphilic molecules such as non steroidal anti inflammatory drugs (NSAIDs) interact and thereby change membrane surface tension. This influences the bending rigidity of the membrane, changes its hydrophobicity fluidity and decreases the mucosal barrier property of the membrane.83

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus