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Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


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Mentions: Lung surfactants possess a key role in normal pulmonary function. Dynamic surface tension of lung surfactants allows the alveoli to remain inflated. An effective lung surfactant must have three properties, as follows: i) The rate of its surface adsorption should generate surface tension of 25 mNm-1 to match that of the air-fluid interface in the lung, during the first breaths and inspiration throughout life. ii) It should be able to prevent alveolar collapse during surface compression/expansion cycle. Surfactant should reduce surface tension to nearly 0 mNm-1 to avoid alveoli collapse. iii) During surface expansion, surfactants should reduce surface tension and decrease the pressure difference needed to maintain ventilatory cycles throughout life ( Fig. 3). Alteration in the surfactant system during pulmonary diseases can be detected with the surface tension analysis. Stress and damage can cause leakage of the blood proteins (such as albumin and fibrinogen) into the lung and interfere with its ability to lower the surface tension and cause difficulty in breathing.46-50


Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401165&req=5

Mentions: Lung surfactants possess a key role in normal pulmonary function. Dynamic surface tension of lung surfactants allows the alveoli to remain inflated. An effective lung surfactant must have three properties, as follows: i) The rate of its surface adsorption should generate surface tension of 25 mNm-1 to match that of the air-fluid interface in the lung, during the first breaths and inspiration throughout life. ii) It should be able to prevent alveolar collapse during surface compression/expansion cycle. Surfactant should reduce surface tension to nearly 0 mNm-1 to avoid alveoli collapse. iii) During surface expansion, surfactants should reduce surface tension and decrease the pressure difference needed to maintain ventilatory cycles throughout life ( Fig. 3). Alteration in the surfactant system during pulmonary diseases can be detected with the surface tension analysis. Stress and damage can cause leakage of the blood proteins (such as albumin and fibrinogen) into the lung and interfere with its ability to lower the surface tension and cause difficulty in breathing.46-50

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus