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Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Research has revealed that forces generated by surface tension play a leading role in the position rearrangement of cells and act in minimizing the exposed area of the aggregate. Cell-cell adhesion is maintained through specific adhesion molecules such as cadherins which are expressed on the cell surface. Due to the different adhesion molecules on various cell types, intensity of adhesion among cells happen to markedly varry.23,24 This phenomenon is responsible for the cell migration and is explained by differential adhesion hypothesis. This hypothesis explains adhesion-driven morphogenic processes in the early embryonic development. Expression of different cadherins changes the cell surface contact and controls the cell shape. Regulation of these adhesion molecules in different cell groups determines cell shape and helps to gain information about cellular aggregates in order to decide on the next migration step. As shown in Fig. 2, it can be deduced that when cells with different adhesive forces are put together, the less adhesive cells migrate gradually and surround the more adhesive cells.17,25,26 Taken all, cell adhesion studies will help to understand how organisms are built and how controlling these forces can help to prevent cancer and other human diseases. Both cell-cell cohesion and cell-matrix interactions are responsible for cell configuration and malignant invasion.27,28


Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401165&req=5

Mentions: Research has revealed that forces generated by surface tension play a leading role in the position rearrangement of cells and act in minimizing the exposed area of the aggregate. Cell-cell adhesion is maintained through specific adhesion molecules such as cadherins which are expressed on the cell surface. Due to the different adhesion molecules on various cell types, intensity of adhesion among cells happen to markedly varry.23,24 This phenomenon is responsible for the cell migration and is explained by differential adhesion hypothesis. This hypothesis explains adhesion-driven morphogenic processes in the early embryonic development. Expression of different cadherins changes the cell surface contact and controls the cell shape. Regulation of these adhesion molecules in different cell groups determines cell shape and helps to gain information about cellular aggregates in order to decide on the next migration step. As shown in Fig. 2, it can be deduced that when cells with different adhesive forces are put together, the less adhesive cells migrate gradually and surround the more adhesive cells.17,25,26 Taken all, cell adhesion studies will help to understand how organisms are built and how controlling these forces can help to prevent cancer and other human diseases. Both cell-cell cohesion and cell-matrix interactions are responsible for cell configuration and malignant invasion.27,28

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus