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Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus

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Mentions: Intracellular adhesion and repulsion between various cell types cause mobility within cells. Cellular forces are essential for the process of cell coupling, cell morphology and tissue rearrangement.19-21 The resulting balance of intracellular and extracellular forces defines the geometrical shape of the cell and lead to rounding of the tissue which helps to minimize its surface tension and to maximize the intracellular adhesion. Fig. 1 is the schematic representation of interaction between cortical tension and cellular adhesion during the formation of cell–cell contact. Adhesion contact on neighbouring cells ensures stable organization of tissues. Three kinds of forces, cortical tension, cellular adhesion and cellular viscoelastic properties are mechanically coupled to each other. Interaction between these mechanical properties governs cell shape and cell arrangement in tissues. These forces regulate cellular behaviours such as tissue development, embryogenesis, protein expression, cell proliferation and differentiation and will help to study the cell behaviour in normal and pathological conditions and invasiveness of malignant tumors.18-22


Surface tension in human pathophysiology and its application as a medical diagnostic tool.

Fathi-Azarbayjani A, Jouyban A - Bioimpacts (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401165&req=5

Mentions: Intracellular adhesion and repulsion between various cell types cause mobility within cells. Cellular forces are essential for the process of cell coupling, cell morphology and tissue rearrangement.19-21 The resulting balance of intracellular and extracellular forces defines the geometrical shape of the cell and lead to rounding of the tissue which helps to minimize its surface tension and to maximize the intracellular adhesion. Fig. 1 is the schematic representation of interaction between cortical tension and cellular adhesion during the formation of cell–cell contact. Adhesion contact on neighbouring cells ensures stable organization of tissues. Three kinds of forces, cortical tension, cellular adhesion and cellular viscoelastic properties are mechanically coupled to each other. Interaction between these mechanical properties governs cell shape and cell arrangement in tissues. These forces regulate cellular behaviours such as tissue development, embryogenesis, protein expression, cell proliferation and differentiation and will help to study the cell behaviour in normal and pathological conditions and invasiveness of malignant tumors.18-22

Bottom Line: Pathological features of disease appear to be quite different.It is well accepted that no single biomarker will be effective in clinical diagnosis.The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

ABSTRACT

Introduction: Pathological features of disease appear to be quite different. Despite this diversity, the common feature of various disorders underlies physicochemical and biochemical factors such as surface tension. Human biological fluids comprise various proteins and phospholipids which are capable of adsorption at fluid interfaces and play a vital role in the physiological function of human organs. Surface tension of body fluids correlates directly to the development of pathological states.

Methods: In this review, the variety of human diseases mediated by the surface tension changes of biological phenomena and the failure of biological fluids to remain in their native state are discussed.

Results: Dynamic surface tension measurements of human biological fluids depend on various parameters such as sex, age and changes during pregnancy or certain disease. It is expected that studies of surface tension behavior of human biological fluids will provide additional information and might become useful in medical practice. Theoretical background on surface tension measurement and surface tension values of reference fluids obtained from healthy and sick patients are depicted.

Conclusion: It is well accepted that no single biomarker will be effective in clinical diagnosis. The surface tension measurement combined with routine lab tests may be a novel non-invasive method which can not only facilitate the discovery of diagnostic models for various diseases and its severity, but also be a useful tool for monitoring treatment efficacy. We therefore expect that studies of surface tension behavior of human biological fluids will provide additional useful information in medical practice.

No MeSH data available.


Related in: MedlinePlus