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Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction.

Cruz-Gonzalez I, Pabón P, Rodríguez-Barbero A, Martín-Moreiras J, Pericacho M, Sánchez PL, Ramirez V, Sánchez-Ledesma M, Martín-Herrero F, Jiménez-Candil J, Maree AO, Sánchez-Rodríguez A, Martín-Luengo C, López-Novoa JM - J. Cell. Mol. Med. (2008)

Bottom Line: Endoglin levels in AMI patients on admission were significantly lower than in healthy controls (4.25 +/- 0.99 ng/ml versus 4.59 +/- 0.87 ng/ml; P= 0.013), and decreased further in the first 48 hours (3.65 +/- 0.76 ng/ml, P < 0.001).Upon follow-up (median 319 days), patients who died had a significantly greater decrease in serum endoglin level over the first 48 hrs than those who survived (1.03 +/- 0.91 versus 0.54 +/- 0.55 ng/ml; P= 0.025).In conclusion, early changes in serum endoglin may predict mortality after AMI.

View Article: PubMed Central - PubMed

Affiliation: Cardiology Division, University Hospital of Salamanca, Salamanca, Spain.

ABSTRACT
Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial infarction (AMI) are not known. In this observational prospective study serum endoglin levels were measured by ELISA in 183 AMI patients upon admission to hospital and 48 hrs later and in 72 healthy controls. Endoglin levels in AMI patients on admission were significantly lower than in healthy controls (4.25 +/- 0.99 ng/ml versus 4.59 +/- 0.87 ng/ml; P= 0.013), and decreased further in the first 48 hours (3.65 +/- 0.76 ng/ml, P < 0.001). Upon follow-up (median 319 days), patients who died had a significantly greater decrease in serum endoglin level over the first 48 hrs than those who survived (1.03 +/- 0.91 versus 0.54 +/- 0.55 ng/ml; P= 0.025). Endoglin decrease was an independent predictor of short-term (30 days) (hazard ratio 2.33;95% CI = 1.27-4.23; P= 0.006) cardiovascular mortality, and also predicts overall cardiovascular mortality during the follow-up (median 319 days) in AMI patients (hazard ratio 2.13;95% CI = 1.20-3.78; P= 0.01). In conclusion, early changes in serum endoglin may predict mortality after AMI.

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Related in: MedlinePlus

Endoglin levels in healthy control subjects and in patients with acute myocardial infarction. Boxplot showing serum levels of endoglin in healthy control subjects and patients with acute myocardial infarction (AMI) on admission and after 48 hrs. The horizontal line in the center of the box represents the 50th percentile, the ends of the box represent the 25th and 75th percentiles, the tips of the whiskers represent the 5th and 95th percentiles and the closed circles indicate individual outliers.
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fig01: Endoglin levels in healthy control subjects and in patients with acute myocardial infarction. Boxplot showing serum levels of endoglin in healthy control subjects and patients with acute myocardial infarction (AMI) on admission and after 48 hrs. The horizontal line in the center of the box represents the 50th percentile, the ends of the box represent the 25th and 75th percentiles, the tips of the whiskers represent the 5th and 95th percentiles and the closed circles indicate individual outliers.

Mentions: Acute MI patients had significantly lower serum endoglin levels on admission compared to healthy controls (4.25 ± 0.99 versus 4.59 ± 0.87 ng/ml; P= 0.013). Forty-eight hours after admission endoglin levels in AMI patients were even lower (4.25 ± 0.99 versus 3.65 ± 0.76 ng/ml; P <0.001) (Fig. 1). Diabetes, dyslidipemia and prior MI were associated with significantly lower admission endoglin levels. No demographic variable significantly influenced the extent of decrease in endoglin level in the first 48 hrs.(Table 1)


Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction.

Cruz-Gonzalez I, Pabón P, Rodríguez-Barbero A, Martín-Moreiras J, Pericacho M, Sánchez PL, Ramirez V, Sánchez-Ledesma M, Martín-Herrero F, Jiménez-Candil J, Maree AO, Sánchez-Rodríguez A, Martín-Luengo C, López-Novoa JM - J. Cell. Mol. Med. (2008)

Endoglin levels in healthy control subjects and in patients with acute myocardial infarction. Boxplot showing serum levels of endoglin in healthy control subjects and patients with acute myocardial infarction (AMI) on admission and after 48 hrs. The horizontal line in the center of the box represents the 50th percentile, the ends of the box represent the 25th and 75th percentiles, the tips of the whiskers represent the 5th and 95th percentiles and the closed circles indicate individual outliers.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401139&req=5

fig01: Endoglin levels in healthy control subjects and in patients with acute myocardial infarction. Boxplot showing serum levels of endoglin in healthy control subjects and patients with acute myocardial infarction (AMI) on admission and after 48 hrs. The horizontal line in the center of the box represents the 50th percentile, the ends of the box represent the 25th and 75th percentiles, the tips of the whiskers represent the 5th and 95th percentiles and the closed circles indicate individual outliers.
Mentions: Acute MI patients had significantly lower serum endoglin levels on admission compared to healthy controls (4.25 ± 0.99 versus 4.59 ± 0.87 ng/ml; P= 0.013). Forty-eight hours after admission endoglin levels in AMI patients were even lower (4.25 ± 0.99 versus 3.65 ± 0.76 ng/ml; P <0.001) (Fig. 1). Diabetes, dyslidipemia and prior MI were associated with significantly lower admission endoglin levels. No demographic variable significantly influenced the extent of decrease in endoglin level in the first 48 hrs.(Table 1)

Bottom Line: Endoglin levels in AMI patients on admission were significantly lower than in healthy controls (4.25 +/- 0.99 ng/ml versus 4.59 +/- 0.87 ng/ml; P= 0.013), and decreased further in the first 48 hours (3.65 +/- 0.76 ng/ml, P < 0.001).Upon follow-up (median 319 days), patients who died had a significantly greater decrease in serum endoglin level over the first 48 hrs than those who survived (1.03 +/- 0.91 versus 0.54 +/- 0.55 ng/ml; P= 0.025).In conclusion, early changes in serum endoglin may predict mortality after AMI.

View Article: PubMed Central - PubMed

Affiliation: Cardiology Division, University Hospital of Salamanca, Salamanca, Spain.

ABSTRACT
Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial infarction (AMI) are not known. In this observational prospective study serum endoglin levels were measured by ELISA in 183 AMI patients upon admission to hospital and 48 hrs later and in 72 healthy controls. Endoglin levels in AMI patients on admission were significantly lower than in healthy controls (4.25 +/- 0.99 ng/ml versus 4.59 +/- 0.87 ng/ml; P= 0.013), and decreased further in the first 48 hours (3.65 +/- 0.76 ng/ml, P < 0.001). Upon follow-up (median 319 days), patients who died had a significantly greater decrease in serum endoglin level over the first 48 hrs than those who survived (1.03 +/- 0.91 versus 0.54 +/- 0.55 ng/ml; P= 0.025). Endoglin decrease was an independent predictor of short-term (30 days) (hazard ratio 2.33;95% CI = 1.27-4.23; P= 0.006) cardiovascular mortality, and also predicts overall cardiovascular mortality during the follow-up (median 319 days) in AMI patients (hazard ratio 2.13;95% CI = 1.20-3.78; P= 0.01). In conclusion, early changes in serum endoglin may predict mortality after AMI.

Show MeSH
Related in: MedlinePlus