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Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease.

Makinde T, Agrawal DK - J. Cell. Mol. Med. (2008)

Bottom Line: Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent.Ang-1 has an anti-inflammatory effect, when co-localized with vascular endothelial growth factor (VEGF) in the vasculature.In this article, we have summarized and critically reviewed the pathophysiological role of Ang-1-Tie2 signalling pathway.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.

ABSTRACT
Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent. Deficiency in either Ang-1 or Tie2 protein leads to severe microvascular defects and subsequent embryonic lethality in murine model. Tie2 receptors are expressed in several cell types, including endothelial cells, smooth muscle cells, fibroblasts, epithelial cells, monocytes, neutrophils, eosinophils and glial cells. Ang-1-Tie2 signalling induces a chemotactic effect in smooth muscle cells, neutrophils and eosinophils, and induces differentiation of mesenchymal cells to smooth muscle cells. Additionally, this signalling pathway induces the secretion of serotonin, matrix metalloproteinases (MMPs) and plasmin. Ang-1 inhibits the secretion of tissue inhibitor of matrix metalloproteinase (TIMPs). Aberrant expression and activity of Tie2 in vascular and non-vascular cells may result in the development of rheumatoid arthritis, cancer, hypertension and psoriasis. Ang-1 has an anti-inflammatory effect, when co-localized with vascular endothelial growth factor (VEGF) in the vasculature. Thus, Ang-1 could be potentially important in the therapy of various pathological conditions such as pulmonary hypertension, arteriosclerosis and diabetic retinopathy. In this article, we have summarized and critically reviewed the pathophysiological role of Ang-1-Tie2 signalling pathway.

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Illustration of the relationship between Ang-1-Tie2 signallingsignaling and pathological conditions. Ang-1-Tie2 signallingsignaling induces various responses in different cells and these responses contribute to the development of various pathological conditions.
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fig04: Illustration of the relationship between Ang-1-Tie2 signallingsignaling and pathological conditions. Ang-1-Tie2 signallingsignaling induces various responses in different cells and these responses contribute to the development of various pathological conditions.

Mentions: There is sufficient evidence to suggest that both beneficial and deleterious effects can be exerted through the activation of Tie2. Within the scope of this article, summary of the role of Ang-1-Tie2 signalling pathway in rheumatoid arthritis, tumour progression, and asthma is presented in the following section (Fig. 4).


Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease.

Makinde T, Agrawal DK - J. Cell. Mol. Med. (2008)

Illustration of the relationship between Ang-1-Tie2 signallingsignaling and pathological conditions. Ang-1-Tie2 signallingsignaling induces various responses in different cells and these responses contribute to the development of various pathological conditions.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401129&req=5

fig04: Illustration of the relationship between Ang-1-Tie2 signallingsignaling and pathological conditions. Ang-1-Tie2 signallingsignaling induces various responses in different cells and these responses contribute to the development of various pathological conditions.
Mentions: There is sufficient evidence to suggest that both beneficial and deleterious effects can be exerted through the activation of Tie2. Within the scope of this article, summary of the role of Ang-1-Tie2 signalling pathway in rheumatoid arthritis, tumour progression, and asthma is presented in the following section (Fig. 4).

Bottom Line: Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent.Ang-1 has an anti-inflammatory effect, when co-localized with vascular endothelial growth factor (VEGF) in the vasculature.In this article, we have summarized and critically reviewed the pathophysiological role of Ang-1-Tie2 signalling pathway.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA.

ABSTRACT
Angiopoietin-1 (Ang-1) is the primary agonist for Tie2 tyrosine kinase receptor (Tie2), and the effect of Ang-1-Tie2 signalling is context-dependent. Deficiency in either Ang-1 or Tie2 protein leads to severe microvascular defects and subsequent embryonic lethality in murine model. Tie2 receptors are expressed in several cell types, including endothelial cells, smooth muscle cells, fibroblasts, epithelial cells, monocytes, neutrophils, eosinophils and glial cells. Ang-1-Tie2 signalling induces a chemotactic effect in smooth muscle cells, neutrophils and eosinophils, and induces differentiation of mesenchymal cells to smooth muscle cells. Additionally, this signalling pathway induces the secretion of serotonin, matrix metalloproteinases (MMPs) and plasmin. Ang-1 inhibits the secretion of tissue inhibitor of matrix metalloproteinase (TIMPs). Aberrant expression and activity of Tie2 in vascular and non-vascular cells may result in the development of rheumatoid arthritis, cancer, hypertension and psoriasis. Ang-1 has an anti-inflammatory effect, when co-localized with vascular endothelial growth factor (VEGF) in the vasculature. Thus, Ang-1 could be potentially important in the therapy of various pathological conditions such as pulmonary hypertension, arteriosclerosis and diabetic retinopathy. In this article, we have summarized and critically reviewed the pathophysiological role of Ang-1-Tie2 signalling pathway.

Show MeSH
Related in: MedlinePlus