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The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia.

de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E - Endocr Connect (2015)

Bottom Line: We compared initial test results with the final clinical diagnosis, i.e., no DI, central DI, or nephrogenic DI.Plasma AVP levels did not differ between patient groups and did not differentiate among central DI, nephrogenic DI, or PP.Differentiating between central and nephrogenic DI should be based on clinical judgment as AVP levels did not discriminate.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and MetabolismRoom F5-164Laboratory of EndocrinologyDepartment of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands m.defost@amc.uva.nl.

No MeSH data available.


Related in: MedlinePlus

AVP and CP during water deprivation in a subject with PP (A) and a subject with central DI (B). DI, diabetes insipidus; AVP, arginine vasopressin; CP, copeptin.
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fig2: AVP and CP during water deprivation in a subject with PP (A) and a subject with central DI (B). DI, diabetes insipidus; AVP, arginine vasopressin; CP, copeptin.

Mentions: In two patients, hourly CP and AVP data were available (Fig. 2). Patient A did not have DI, and CP levels clearly increased during the test, while AVP levels remained low (Fig. 2). In patient B, who had central DI, both AVP and CP plasma levels remained low (Fig. 2).


The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia.

de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E - Endocr Connect (2015)

AVP and CP during water deprivation in a subject with PP (A) and a subject with central DI (B). DI, diabetes insipidus; AVP, arginine vasopressin; CP, copeptin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401105&req=5

fig2: AVP and CP during water deprivation in a subject with PP (A) and a subject with central DI (B). DI, diabetes insipidus; AVP, arginine vasopressin; CP, copeptin.
Mentions: In two patients, hourly CP and AVP data were available (Fig. 2). Patient A did not have DI, and CP levels clearly increased during the test, while AVP levels remained low (Fig. 2). In patient B, who had central DI, both AVP and CP plasma levels remained low (Fig. 2).

Bottom Line: We compared initial test results with the final clinical diagnosis, i.e., no DI, central DI, or nephrogenic DI.Plasma AVP levels did not differ between patient groups and did not differentiate among central DI, nephrogenic DI, or PP.Differentiating between central and nephrogenic DI should be based on clinical judgment as AVP levels did not discriminate.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and MetabolismRoom F5-164Laboratory of EndocrinologyDepartment of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands m.defost@amc.uva.nl.

No MeSH data available.


Related in: MedlinePlus