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The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia.

de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E - Endocr Connect (2015)

Bottom Line: We compared initial test results with the final clinical diagnosis, i.e., no DI, central DI, or nephrogenic DI.Plasma AVP levels did not differ between patient groups and did not differentiate among central DI, nephrogenic DI, or PP.Differentiating between central and nephrogenic DI should be based on clinical judgment as AVP levels did not discriminate.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and MetabolismRoom F5-164Laboratory of EndocrinologyDepartment of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands m.defost@amc.uva.nl.

No MeSH data available.


Related in: MedlinePlus

Plasma osmolality vs AVP (A) and CP (B) at the end of the water deprivation test. Arrows depict patient 1 (in the central DI group) and patient 2 (in the no DI group). DI, diabetes insipidus; CP, copeptin.
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fig1: Plasma osmolality vs AVP (A) and CP (B) at the end of the water deprivation test. Arrows depict patient 1 (in the central DI group) and patient 2 (in the no DI group). DI, diabetes insipidus; CP, copeptin.

Mentions: Plasma AVP levels at the time of discontinuation of the test showed considerable overlap between patient groups (no DI: 0.8 pmol/l (0.1–4.0 pmol/l), central DI: 0.5 pmol/l (0.1–4.3 pmol/l) (P=0.5), nephrogenic DI 11.0 pmol/l) (Fig. 1).


The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia.

de Fost M, Oussaada SM, Endert E, Linthorst GE, Serlie MJ, Soeters MR, DeVries JH, Bisschop PH, Fliers E - Endocr Connect (2015)

Plasma osmolality vs AVP (A) and CP (B) at the end of the water deprivation test. Arrows depict patient 1 (in the central DI group) and patient 2 (in the no DI group). DI, diabetes insipidus; CP, copeptin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401105&req=5

fig1: Plasma osmolality vs AVP (A) and CP (B) at the end of the water deprivation test. Arrows depict patient 1 (in the central DI group) and patient 2 (in the no DI group). DI, diabetes insipidus; CP, copeptin.
Mentions: Plasma AVP levels at the time of discontinuation of the test showed considerable overlap between patient groups (no DI: 0.8 pmol/l (0.1–4.0 pmol/l), central DI: 0.5 pmol/l (0.1–4.3 pmol/l) (P=0.5), nephrogenic DI 11.0 pmol/l) (Fig. 1).

Bottom Line: We compared initial test results with the final clinical diagnosis, i.e., no DI, central DI, or nephrogenic DI.Plasma AVP levels did not differ between patient groups and did not differentiate among central DI, nephrogenic DI, or PP.Differentiating between central and nephrogenic DI should be based on clinical judgment as AVP levels did not discriminate.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and MetabolismRoom F5-164Laboratory of EndocrinologyDepartment of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands m.defost@amc.uva.nl.

No MeSH data available.


Related in: MedlinePlus