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Gender difference in adrenal sensitivity to ACTH is abolished in type 2 diabetes.

Arnetz L, Rajamand Ekberg N, Brismar K, Alvarsson M - Endocr Connect (2015)

Bottom Line: Healthy women exhibited higher peak cortisol levels compared with healthy men (675±26 vs 582±21 nmol/l, P=0.014), while the peak levels were equally high in men and women with T2D, resulting in a higher peak level in men with T2D compared with healthy men (691±42 vs 582±21 nmol/l, P=0.024).Serum cortisol concentration after administration of dexamethasone did not differ between the groups, nor did IGF1 and IGFBP1.Men with T2D had a higher peak cortisol compared with controls.

View Article: PubMed Central - PubMed

Affiliation: Departments of EndocrinologyMetabolism and DiabetesMolecular Medicine and SurgeryKarolinska Institutet, Karolinska University Hospital Solna, D2:04, 17176 Stockholm, Sweden Departments of EndocrinologyMetabolism and DiabetesMolecular Medicine and SurgeryKarolinska Institutet, Karolinska University Hospital Solna, D2:04, 17176 Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus

Serum cortisol before, and at peak after, 1 μg ACTH injection.
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fig1: Serum cortisol before, and at peak after, 1 μg ACTH injection.

Mentions: After ACTH injection, healthy women had higher peak cortisol levels (P=0.023) compared with healthy men (Fig. 1 and Table 3). Despite similar basal cortisol levels, the T2D group had higher peak cortisol levels (P=0.043). This was due to higher peak cortisol levels in men with T2D compared with male controls (P=0.024), while peak levels did not differ between healthy and diabetic women. The incremental area under the curve for cortisol was also higher in healthy women than in men (P=0.022), while, as with peak cortisol levels, there was no gender difference in T2D patients. Both men and women with T2D had peak cortisol levels similar to those of healthy women. Basal but not peak cortisol levels correlated with BMI (r=−0.461, P=0.004) and waist circumference (r=−0.467, P=0.003) in healthy subjects but not in T2D patients.


Gender difference in adrenal sensitivity to ACTH is abolished in type 2 diabetes.

Arnetz L, Rajamand Ekberg N, Brismar K, Alvarsson M - Endocr Connect (2015)

Serum cortisol before, and at peak after, 1 μg ACTH injection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4401103&req=5

fig1: Serum cortisol before, and at peak after, 1 μg ACTH injection.
Mentions: After ACTH injection, healthy women had higher peak cortisol levels (P=0.023) compared with healthy men (Fig. 1 and Table 3). Despite similar basal cortisol levels, the T2D group had higher peak cortisol levels (P=0.043). This was due to higher peak cortisol levels in men with T2D compared with male controls (P=0.024), while peak levels did not differ between healthy and diabetic women. The incremental area under the curve for cortisol was also higher in healthy women than in men (P=0.022), while, as with peak cortisol levels, there was no gender difference in T2D patients. Both men and women with T2D had peak cortisol levels similar to those of healthy women. Basal but not peak cortisol levels correlated with BMI (r=−0.461, P=0.004) and waist circumference (r=−0.467, P=0.003) in healthy subjects but not in T2D patients.

Bottom Line: Healthy women exhibited higher peak cortisol levels compared with healthy men (675±26 vs 582±21 nmol/l, P=0.014), while the peak levels were equally high in men and women with T2D, resulting in a higher peak level in men with T2D compared with healthy men (691±42 vs 582±21 nmol/l, P=0.024).Serum cortisol concentration after administration of dexamethasone did not differ between the groups, nor did IGF1 and IGFBP1.Men with T2D had a higher peak cortisol compared with controls.

View Article: PubMed Central - PubMed

Affiliation: Departments of EndocrinologyMetabolism and DiabetesMolecular Medicine and SurgeryKarolinska Institutet, Karolinska University Hospital Solna, D2:04, 17176 Stockholm, Sweden Departments of EndocrinologyMetabolism and DiabetesMolecular Medicine and SurgeryKarolinska Institutet, Karolinska University Hospital Solna, D2:04, 17176 Stockholm, Sweden.

No MeSH data available.


Related in: MedlinePlus