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Antioxidant vitamin C prevents decline in endothelial function during sitting.

Thosar SS, Bielko SL, Wiggins CC, Klaunig JE, Mather KJ, Wallace JP - Med. Sci. Monit. (2015)

Bottom Line: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001).Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Indiana University School of Public Health, Indiana University, Bloomington, IN, USA.

ABSTRACT

Background: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.

Material and methods: Eleven men (24.2 ± 4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h.

Results: By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05).

Conclusions: Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.

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Related in: MedlinePlus

FMD in the superficial femoral artery during 3 h of sitting during the sitting (SIT) and Vitamin C (VIT). Error bars represent standard deviations. * Indicates significant difference between trials at p≤0.05. # Indicates significant difference from baseline. Error bars represent standard deviation.
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f2-medscimonit-21-1015: FMD in the superficial femoral artery during 3 h of sitting during the sitting (SIT) and Vitamin C (VIT). Error bars represent standard deviations. * Indicates significant difference between trials at p≤0.05. # Indicates significant difference from baseline. Error bars represent standard deviation.

Mentions: We recruited and tested 12 healthy, inactive participants (See Table 1 for subject characteristics). We had an incomplete ultrasound image at 1 time point on 1 subject and this subject was omitted from all analysis. As a result, data on 11 participants is presented.


Antioxidant vitamin C prevents decline in endothelial function during sitting.

Thosar SS, Bielko SL, Wiggins CC, Klaunig JE, Mather KJ, Wallace JP - Med. Sci. Monit. (2015)

FMD in the superficial femoral artery during 3 h of sitting during the sitting (SIT) and Vitamin C (VIT). Error bars represent standard deviations. * Indicates significant difference between trials at p≤0.05. # Indicates significant difference from baseline. Error bars represent standard deviation.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401065&req=5

f2-medscimonit-21-1015: FMD in the superficial femoral artery during 3 h of sitting during the sitting (SIT) and Vitamin C (VIT). Error bars represent standard deviations. * Indicates significant difference between trials at p≤0.05. # Indicates significant difference from baseline. Error bars represent standard deviation.
Mentions: We recruited and tested 12 healthy, inactive participants (See Table 1 for subject characteristics). We had an incomplete ultrasound image at 1 time point on 1 subject and this subject was omitted from all analysis. As a result, data on 11 participants is presented.

Bottom Line: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001).Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Indiana University School of Public Health, Indiana University, Bloomington, IN, USA.

ABSTRACT

Background: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.

Material and methods: Eleven men (24.2 ± 4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h.

Results: By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05).

Conclusions: Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.

Show MeSH
Related in: MedlinePlus