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Antioxidant vitamin C prevents decline in endothelial function during sitting.

Thosar SS, Bielko SL, Wiggins CC, Klaunig JE, Mather KJ, Wallace JP - Med. Sci. Monit. (2015)

Bottom Line: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001).Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Indiana University School of Public Health, Indiana University, Bloomington, IN, USA.

ABSTRACT

Background: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.

Material and methods: Eleven men (24.2 ± 4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h.

Results: By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05).

Conclusions: Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.

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Related in: MedlinePlus

Study design. SIT represents prolonged 3 h of sitting. VIT represents prolonged sitting with intermittent vitamin C. FMD was measured at 0, 1, 2, and 3 h. ● Represents vitamin C. Participants ingested 1 g vitamin C at 30 min and 500 mg at 1 h 30 min.
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f1-medscimonit-21-1015: Study design. SIT represents prolonged 3 h of sitting. VIT represents prolonged sitting with intermittent vitamin C. FMD was measured at 0, 1, 2, and 3 h. ● Represents vitamin C. Participants ingested 1 g vitamin C at 30 min and 500 mg at 1 h 30 min.

Mentions: The purpose of the current study was to determine if antioxidant Vitamin C prevents the decline in SFA endothelial function during prolonged sitting. We hypothesized that there would be a significant decline in SFA FMD from baseline during 3 h of sitting. Previous studies from our lab and others have demonstrated vitamin C to be effective in preventing the oxidative stress-mediated decline in endothelial function in a variety of physiological stressors, including, but not limited to, hypertension [14] and increased retrograde shear [15]. Therefore, we hypothesized that vitamin C would prevent the decline in SFA endothelial function during 3 h of sitting.


Antioxidant vitamin C prevents decline in endothelial function during sitting.

Thosar SS, Bielko SL, Wiggins CC, Klaunig JE, Mather KJ, Wallace JP - Med. Sci. Monit. (2015)

Study design. SIT represents prolonged 3 h of sitting. VIT represents prolonged sitting with intermittent vitamin C. FMD was measured at 0, 1, 2, and 3 h. ● Represents vitamin C. Participants ingested 1 g vitamin C at 30 min and 500 mg at 1 h 30 min.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4401065&req=5

f1-medscimonit-21-1015: Study design. SIT represents prolonged 3 h of sitting. VIT represents prolonged sitting with intermittent vitamin C. FMD was measured at 0, 1, 2, and 3 h. ● Represents vitamin C. Participants ingested 1 g vitamin C at 30 min and 500 mg at 1 h 30 min.
Mentions: The purpose of the current study was to determine if antioxidant Vitamin C prevents the decline in SFA endothelial function during prolonged sitting. We hypothesized that there would be a significant decline in SFA FMD from baseline during 3 h of sitting. Previous studies from our lab and others have demonstrated vitamin C to be effective in preventing the oxidative stress-mediated decline in endothelial function in a variety of physiological stressors, including, but not limited to, hypertension [14] and increased retrograde shear [15]. Therefore, we hypothesized that vitamin C would prevent the decline in SFA endothelial function during 3 h of sitting.

Bottom Line: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001).Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates.

View Article: PubMed Central - PubMed

Affiliation: Department of Kinesiology, Indiana University School of Public Health, Indiana University, Bloomington, IN, USA.

ABSTRACT

Background: This study was designed to test the hypothesis that antioxidant Vitamin C prevents the impairment of endothelial function during prolonged sitting.

Material and methods: Eleven men (24.2 ± 4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively. Superficial femoral artery (SFA) flow-mediated dilation (FMD) was measured hourly for 3 h.

Results: By a 1-way ANOVA, there was a significant decline in FMD during 3 h of SIT (p<0.001). Simultaneously, there was a significant decline in antegrade (p=0.04) and mean (0.037) shear rates. For the SIT and VIT trials by a 2-way (trial x time) repeated measures ANOVA, there was a significant interaction (p=0.001). Pairwise testing revealed significant between-SFA FMD in the SIT and VIT trial at each hour after baseline, showing that VIT prevented the decline in FMD 1 h (p=0.009), 2 h (p=0.016), and 3 h (p=0.004). There was no difference in the shear rates between SIT and VIT trials (p>0.05).

Conclusions: Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.

Show MeSH
Related in: MedlinePlus